A Systematic Review on Medicinal Plants with Anti – Malarial Properties in Southeast Asia

Shankar, Aissvarya (2021) A Systematic Review on Medicinal Plants with Anti – Malarial Properties in Southeast Asia. [Project Paper] (Submitted)

Text FPSK2 2021 9.pdf Download (2MB)

Abstract

The elevated rise in resistance and adverse effects towards antimalarial drugs in the Southeast Asia (SEA) region addresses the need for new therapeutic approaches. There are various studies conducted on medicinal plants found in SEA as a source for new anti-malarial agents. However, there isn’t a comprehensive summary on the findings of these studies. Objective: This systematic review aims to evaluate the existing evidence and to identify the medicinal plant(s) in the SEA region with high potential of anti-malarial activity. It also aims to compare the IC50 doses & percentage of parasitemia inhibition of medicinal plants with anti-malarial properties in Southeast Asia using statistical tools. Methodology: The systematic search was conducted using a customised search strategy in databases such as PubMed, Science Direct, Scopus, Google Scholar and Wiley Online Library. Data were collected from a total of 36 articles meeting the inclusion criteria. Microsoft Excel was used to summarize the data using descriptive statistics. Results: A total of 115 extracts of 39 plant species from 19 families were categorised as very good, good, moderate, weak and inactive for in vitro and in vivo studies, respectively. Most of the reports are from Thailand followed by Malaysia and Indonesia. Plant species from family Annonaceae contributed the most among these 36 studies. Leaves were reported as the most used part of plants in antimalarial investigation and methanol was the most used solvent for the extraction process. Among the 115 extracts, 77.78% of the tested extracts in in vivo studies showed higher than moderate antimalarial activity followed by 72.85% in in vitro studies and 50% of extracts in mixed design studies. For the risk of bias assessment, most studies presented with low to medium risk of bias. Discussion: Annonaceae family contributed to the most activities as it is widely used to treat malaria. Most good and very good activities came from Asteraceae and Menispermaceae families. Leaves were most used part because they possess ethno pharmacological relevance and antimalarial activity due to the high content of bioactive compounds present. Moreover, alcohol based solvents yielded extraction with the highest bio compound content and biological activity. Conclusion: In comparison to the huge number of naturally occurring plants in Southeast Asia, only a small number of medicinal plant species have been evaluated. Thus, a system for systematically investigating and exploring unexplored plant genera must be devised.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	22 Aug 2023 07:52
Last Modified:	22 Aug 2023 07:52
URI:	http://psaspb.upm.edu.my/id/eprint/1009

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