Kamis, Nurain Irdayani (2021) Effects of propolis on allergic diseases : A systematic review of in vitro, in vivo and clinical studies. [Project Paper] (Submitted)
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Abstract
The prevalence of allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma has been increasing in the global population and the lack of safe and effective treatment for these diseases remains a major challenge. Propolis is a bee product collected from plant parts and exudates. Its phenolic constituents have demonstrated various biological activities, including anti-inflammatory and immunomodulatory effects. However, the potential application of propolis for allergic diseases has not been fully explored. Objectives: This study aimed to conduct a systematic review of studies investigating the effects of propolis on different allergic diseases to support its further development for therapeutic use. Methodology: Relevant articles were retrieved from three electronic databases, PubMed, Scopus and ScienceDirect, using the keywords “propolis” AND “allergy”. All in vitro, in vivo, and clinical studies that met the eligibility criteria were included in the systematic review, followed by the extraction of related findings such as the types of propolis used and their effects in different experimental models. Results: A total of 12 eligible articles consisting of 7 in vitro studies, 7 in vivo studies, and 2 clinical studies were identified. In vitro studies demonstrated that propolis inhibited the release of allergic mediators and cytokines in different cellular models. Propolis ethanolic extract was also able to ameliorate the symptoms of atopic dermatitis and allergic rhinitis in vivo. Besides that, the anti-asthmatic effects of propolis were supported by both in vivo and clinical studies where propolis has been shown to suppress airway inflammation, airway hyperresponsiveness and improve pulmonary function. Notably, propolis treatment showed anti-allergic effects when administered orally for asthma and allergic rhinitis as well as topically for allergic rhinitis and atopic dermatitis in in vivo models, and these were observed regardless of the mode of treatment. Although a clinical study showed that propolis had no effect on allergic sensitization and eczema, it was demonstrated to be a safe supplement for lactating mothers. Discussion: The anti-allergic activities of propolis were likely to be contributed by the active constituents commonly found in propolis. Caffeic acid phenethyl ester (CAPE), tectochrysin and pinocembrin have been shown to have anti-asthmatic effects in vivo, whereas CAPE and chrysin have been shown to attenuate atopic dermatitis-like symptoms. Although propolis in the form of extracts as well as active constituents demonstrated anti-allergic effects, the safety and effectiveness of the active constituents are yet to be evaluated in clinical trial. In contrast, propolis extract formulated as a nutritional food product has been shown to have therapeutic effects for asthma as an adjuvant therapy in the clinical setting and thus, such approach may be adopted for other allergic diseases. Conclusion: Overall, propolis demonstrated beneficial effects for various allergic diseases in pre-clinical studies; however, clinical evidence is lacking for allergic rhinitis and atopic dermatitis. With proven safety for human consumption, the effectiveness of propolis extract for allergic rhinitis and atopic dermatitis could be further evaluated in the clinical setting. It is also worthwhile to further investigate the clinical therapeutic potential of active constituents of propolis for different allergic diseases.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Medicine and Health Science |
| Depositing User: | Ms. Nor Safa'aton Saidin |
| Date Deposited: | 22 Aug 2023 07:46 |
| Last Modified: | 22 Aug 2023 07:46 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1147 |
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