Patient profiles and antimicrobials susceptibility patterns of group b streptococcus isolated from Hospital Serdang since 2010 to 2019

Izudin, Muhamad and Yin, Joanne Lee Kar and Md Nor Azman, Nurul Izzah (2020) Patient profiles and antimicrobials susceptibility patterns of group b streptococcus isolated from Hospital Serdang since 2010 to 2019. [Project Paper] (Submitted)

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Abstract

Introduction: Group B streptococcus (GBS) or known as Streptococcus agalactiae can be isolated from various sites of the body. Patient profiles which consist of data on sociodemographic factors and the types of isolation site of patients were studied. The type of isolation site are categorized into two which are non-invasive (colonizing) or invasive. Sociodemographic factors of patients contribute as a risk factor and outcome of the infection. In 1996, Centre for Disease Control and Prevention published a guideline on GBS and recommended Intrapartum Antibiotics Prophylaxis (IAP) and since then penicillin remained as the first line antibiotic. However, resistance of GBS towards antimicrobials has been increasing nowadays and is being a great concern to many. Objective: The aim of this study is to determine distribution of GBS isolates, sociodemographic factor and antibiotic susceptibility pattern of patients with GBS isolated from their clinical specimens. This study also determines the association of the iii sociodemographic factors and antimicrobials susceptibility with the types of GBS isolation site (non-invasive (colonizing) and Invasive). Methods: A cross sectional study based on data obtained from Hospital Serdang. The total study population was 10388 patients with GBS isolated from their clinical specimens in Hospital Serdang from 2010 to 2019. Incomplete data was excluded from analysis. Simple random sampling method was done, and 379 patients were randomly selected from SPSS. The study duration was from 1st June 2020 until 5th October 2020. Data were analysed using SPSS version 25. Data collection was done via data collection sheet (proforma). Results: This study found that the trend of invasive GBS isolates in Malaysia over a period of 10 years, GBS cases spike in year 2013 but there was a marked decline in year 2014 followed by minimal changes until year 2018. From 379 patients, female (n=352, 92.9%), adults (n=372, 98.2%) and Malay (n=312, 82.3%) have the highest distribution among all patients. There is a significant association between sociodemographic factors and types of GBS isolation site, (p<0.05). Male, children and Chinese were found to be associated with invasive type of GBS isolate, (p<0.05). For antimicrobials susceptibility rate, penicillin (99.2%), ampicillin (97.4%), levofloxacin (95.4%), erythromycin (90.5%), and clindamycin (87.1%). Tetracycline and Trimethoprim-sulfamethoxazole had very high non-susceptible rate with 73.8% and 80.7% respectively. However, there is no association between antimicrobials susceptibility and the types of GBS isolation site (p>0.05). Conclusion: Male, children and Chinese were found to be more likely to be associated with invasive GBS isolates in Hospital Serdang. Penicillin still remain as the drug of iv choice while for clindamycin and erythromycin showed a considerable number to resistance. Trimethoprim-sulfamethoxazole and tetracycline showed a very high resistance rate, thus should not be included in the management of GBS. Keywords: Group B Streptococcus, Sociodemographic factors, Antimicrobials

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	04 Sep 2023 07:25
Last Modified:	04 Sep 2023 07:25
URI:	http://psaspb.upm.edu.my/id/eprint/1220

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