Anti-Nociceptive Effects of Essential Oil Of Zingiber Officinale Roscoe In Hotplate Test In Mice

Zhi, Ying Yap (2020) Anti-Nociceptive Effects of Essential Oil Of Zingiber Officinale Roscoe In Hotplate Test In Mice. [Project Paper] (Submitted)

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Abstract

Nociceptive is a sensation or response towards intense stimulus such as sharp, pricking, and burning, which commonly involve central and peripheral mechanisms. Moreover, it can be due to inflammatory responses as well. Ginger which comes from the family Zingiberaeae is a well-known traditional plant that is consumed to treat fever, stomach-ache or muscle sprain. This study generally is aimed to determine the antinociceptive effects of Ginger Essential Oil (GEO) of Zingiber officinale Roscoe in relieving pain in hot plate test in mice. It is hypothesized that mice that are pre-treated with GEO orally have significant increases in the latency time in the hot plate test as compared to the control. GEO is obtained from the Faculty of Agriculture, Universiti Putra Malaysia. Then, four groups of mice with 6 mice each are pre-treated with different GEO concentrations of 10mg, 30mg and 100mg of GEO, then observe the latency time to show pain behavior which are frontpaw licking and jumping at time intervals between 30 minutes to 300 minutes. The 30mg and 100mg GEO pre-treated groups of mice show significant increase in the latency time as compared to the control group, which indicates that GEO is able to relieve pain in hot plate tested mice. However, mice treated with 10mg do not show significant increase in the latency time. Treatment with GEO able to show anti-nociceptive effect in hotplate test in mice.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	22 Aug 2023 07:56
Last Modified:	22 Aug 2023 07:56
URI:	http://psaspb.upm.edu.my/id/eprint/1342

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