Association Between Inflammatory Bowel Disease and Neurological Disease: A Meta-Analysis

Aminuddin, Muhammad Amir Norman (2022) Association Between Inflammatory Bowel Disease and Neurological Disease: A Meta-Analysis. [Project Paper] (Submitted)

Text FPSK2 2022 44.pdf Download (1MB)

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammation of the GI tract characterized by a relapsing and remitting condition comprising two main distinctive diseases, Crohn’s disease (CD) and ulcerative colitis (UC). IBD complications may involve other organs outside the alimentary tract, called extraintestinal manifestation (EIM). Neurologic involvement associated with IBD is rarely reported but they often represent a major cause of morbidity and a relevant diagnostic issue. The clinical significance of developing IBD-related neurologic complications is significant because early detection and treatment of neurological diseases are critical in preventing major morbidity. Objective: To examine the association between IBD and neurological disease by estimating the summary effect size from multiple studies that have the association between these two diseases based on the construction of a forest plot. Methodology: We searched PubMed, ScienceDirect and EBSCOHOST to retrieve observational studies from inception to December 2021 and screened all the article based on specific eligibility criteria. Data rom the included studies in the meta-analysis were extracted and analyzed by using Revman software to produce a forest plot to determine the heterogeneity, summary effect size and p-value. Result: The forest plot shows that the heterogeneity value is 95%, the summary effect size is 1.42 and the p-value is less than 0.0001. Discussion: There is high heterogeneity across the study since it was more than 75%, where the random-effect model was applied in this meta-analysis. There is a significant difference (p-value < 0.0001) between IBD and neurological disease since p-value less than 0.05 are considered significant. The computing summary effect from the forest plot across the studies produces a value for a risk ratio of 1.42 which is more than 1 (RR > 1), which indicate a higher risk of developing a neurological disease in IBD patient compared to the control/healthy group. Conclusion: There is an association between IBD and neurological disease, where IBD patients have a higher risk of developing a neurological disease in IBD patients compared to the control/healthy group.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	22 Aug 2023 04:37
Last Modified:	22 Aug 2023 04:37
URI:	http://psaspb.upm.edu.my/id/eprint/1394

Actions (login required)

View Item