Health risk assessment of alkenylbenzenes in plant food supplements using margin of exposure approach

Mat Ramle, Akmal Arif (2023) Health risk assessment of alkenylbenzenes in plant food supplements using margin of exposure approach. [Project Paper] (Submitted)

Text 200948 AKMAL ARIF lp FPSK4 2023 25.pdf Download (1MB)

Abstract

Introduction: For a long time, plants have been used as medicines to cure a variety of illnesses since it provides a wide range of functions, including beverage uses, as well as food and dietary supplementation. Plant food supplements (PFS) are dietary supplements made from plant extracts and botanical extracts. PFS are frequently sold in capsules or tablet form and are designed to supplement a person's regular diet. PFS derived from botanicals and botanical preparations are becoming increasingly popular around the world because consumers believe they are safe. However, regardless of their supposed health benefits, these supplements may contain potentially harmful ingredients such as alkenylbenzenes, which is estragole. Alkenylbenzenes are a major class of carcinogenic and genotoxic substances found in PFS. Objectives: The objective of this study is to evaluate the health risk of alkenylbenzenes in PFS using margin of exposure approach (MOE). Methodology: A total of 30 PFS samples have been collected and purchased via Malaysian market and online merchants. Each sample was extracted with methanol before being analysed using Ultra Performance Liquid Chromatography. To estimate consumer exposure to estragole in PFS, the estimated daily intake (EDI) was calculated using quantified estragole concentrations in PFS samples. MOE was used to determine the risk of estragole in the PFS sample. Results and Discussion: Estragole, an alkenylbenzene of interest, was found in 9 of 30 PFS samples. Estragole concentrations in PFS ranged from 55.03 to 418.02 μg/g. The EDI values ranged from 0.99-9.44 μg/kg bw per day. Based on the result obtained, all positive samples have MOE values less than 10 000. This emphasises the importance of risk management, especially for long-term consumption. MOE value of less than 10,000 is a high priority for risk management, whereas the MOE of more than 10,000 is a low priority. Conclusion: In conclusion, the presence of alkenylbenzenes in PFS still raises concern if it is consumed daily over a longer period. Keywords: plant food supplements, health risk assessment, alkenylbenzenes, margin of exposure, estragole

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	17 Apr 2024 07:26
Last Modified:	17 Apr 2024 07:26
URI:	http://psaspb.upm.edu.my/id/eprint/1694

Actions (login required)

View Item