Classification and grading of feline and canine mammary gland tumours (MGT) presented to histopathology laboratory, VLSU, UPM from 2020-2022

Rahmat, Ain Umairah (2022) Classification and grading of feline and canine mammary gland tumours (MGT) presented to histopathology laboratory, VLSU, UPM from 2020-2022. [Project Paper] (Submitted)

Text lp FPV 2022 84.pdf Download (3MB)

Abstract

Histological classification and grading are established prognostic factors for feline and canine mammary gland tumours (MGT). Furthermore, tumour infiltrating lymphocytes (TIL) counts have displayed potential as a prognostic marker in human breast cancer, in contrast to feline and canine mammary carcinoma. The study aims to 1) describe the diversity of histological classification and grade of feline and canine MGT; 2) determine the association between histological grade and classification; and 3) investigate the relationship between TIL with histological classification and grade. Histopathology slides of archived mammary gland samples were classified and graded before TIL were counted and expressed in percentage according to human breast cancer TIL count criteria. Subsequently, tubular carcinoma was the most common subtype in both species (canine, 20%; feline, 60%). Canine MGT exhibiting a more diverse histological classification [simple carcinoma, 47.3% (n=26); non-simple carcinoma, 29.1% (n=16); ductal-associated carcinoma, 18.2% (n=10); special-type carcinoma, 1.8% (n=1) and sarcoma, 3.6% (n=2)] than feline MGT [simple carcinoma, 95.0% (n=38) and ductal-associated carcinoma, 5.0% (n=2)]. There was an association between histological grade and classification in both species (canine p=0.026; feline p<0.001 and p=0.037) MGT. The presence of TIL in canine MGT was highly associated with histological classification (p=0.026), grade (p=0.021), and mitotic count (p=0.025). Meanwhile, TIL count in feline MGT was found to be associated with cellular pleomorphism (p=0.048) and mitotic count (p=0.042). Overall, the findings imply insightful information for future studies on the epidemiology of feline and canine mammary carcinoma and that lymphocytes may contribute to the malignancy of canine MGT

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms Nurhaznita Mahmood
Date Deposited:	30 May 2024 07:57
Last Modified:	30 May 2024 07:57
URI:	http://psaspb.upm.edu.my/id/eprint/1848

Actions (login required)

View Item