Association between indoor air pollutant exposure, respiratory symptom and frequency of micronuclei among primary school children in Kemaman, Terengganu

Tengku Mayusi, Tengku Zatil Aleyya (2017) Association between indoor air pollutant exposure, respiratory symptom and frequency of micronuclei among primary school children in Kemaman, Terengganu. [Project Paper] (Submitted)

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Abstract

INTRODUCTION: The major environment-related healths that threaten children's health is the air pollution. This is due to children are more susceptible to the negative effects of air pollutants than adults because they are the vulnerable group. Micronuclei (MN) frequencies were used as the indicator for identifying potential genotoxic exposure. OBJECTIVE: To determine the association between indoor air pollutants and frequency of micronuclei in exfoliated buccal mucosa among primary school children in Kemaman, Terengganu. METHOD: A cross-sectional comparative study was carried out among primary school children in studied group (N=l0l) and comparative (N=75) group in Kemamam, Terengganu. A set of standardized questionnaire was distributed to the respondent. The level of indoor, outdoor air pollutants and indoor home assessment were done through several instrumentation. PM1 , PM2.5 and PM10 was measured using DusTrak DRX Aerosol Monitor, PbbRAE used to measure VOCs while LaMotte Air Sampler was used to monitor NO2 and SO2. IAQ assessment had been carried out in a total of 7 schools and 78 houses of respondents. For exfoliated buccal mucosa, sample was collected and analysed to determine the frequency of Micronuclei (MN). RESULT: There was a significant difference in the concentration of PM1 , PM2_5, PM10, Carbon dioxide (CO2) and Sulphur dioxide (SO2) between studied and comparative group as (Z= -2.752, p=0.006) (Z= -2.793, p=0.005) (Z= -3.643, p=0.000), (Z= -3.179, p=0.001 ), ( Z= -3.114,p=0.002) respectively. There was also a significant association between level of MN frequency in the study area as (z = 7.894 and p=0.00). There was a significant difference between MN frequency and indoor air pollutants as PM1 (p<0.001), PM2_5 (p<0.001), PM10 (p<0.001) and CO2 (p<0.001). CONCLUSION: The finding concluded that primary school children nearby petrochemical industry area were highly exposed to indoor air pollutant compared to those from the comparative group located far from petrochemical industry area. This was proven by there was a significant association between indoor air pollutants and frequency of micronuclei in exfoliated buccal mucosa among primary school children in Kemaman, Terengganu. Keywords: Indoor Air pollutants, Micronuclei (MN) frequency, exfoliated buccal mucosa, respiratory symptom

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	08 Aug 2024 03:56
Last Modified:	08 Aug 2024 03:56
URI:	http://psaspb.upm.edu.my/id/eprint/2023

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