Metabolic profiling of small ruminants affected with lameness and hoof disorders based on substance p and b-hydroxy butyrate assessment

Ahmad Tajuddin, Alya Afida (2023) Metabolic profiling of small ruminants affected with lameness and hoof disorders based on substance p and b-hydroxy butyrate assessment. [Project Paper] (Submitted)

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Abstract

Lameness is a major health, welfare, and productivity concern in small ruminants (sheep and goats). Most cases of lameness arise from hoof disorders, which are considered to elicit pain and metabolic alterations in animals. Nevertheless, there is limited information on the metabolic profile of small ruminants affected with lameness and hoof disorders. Substance P and B-hydroxybutyrate have been demonstrated as reliable indicators of the metabolic profile of lame animals. This cross-sectional study investigated the metabolic profile of lame sheep and goats by assessing the levels of substance P and B-hydroxybutyrate. A total of 48 small ruminants (24 sheep and 24 goats) were conveniently sampled from 5 Ladang Angkat Farms of Universiti Putra Malaysia. Lameness was assessed using a five-point locomotion scoring and animals with a score of 3 and above were considered lame. Hoof disorders and animal characteristics were recorded accordingly. Blood samples were collected and analysed for serum ß-hydroxybutyrate (BHB) and plasma Substance P (SP) levels using commercial ELISA kits. Data were analysed using descriptive statistics and independent t-tests. No significant difference was detected in SP levels between lame and non-lame groups, as well as between the presence or absence of hoof disorders. Meanwhile, although the lame group and those with hoof disorders had higher BHB levels compared to the non-lame and those without hoof disorders, the difference was not statistically significant (p > .05). The relatively small sample size and cross-sectional design might contribute to these findings. Nevertheless, this study can be used as a preliminary work for further analysis to elucidate the alterations in the metabolic profile of lameness and hoof diseases in small ruminants.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms Nurhaznita Mahmood
Date Deposited:	08 Aug 2024 00:50
Last Modified:	08 Aug 2024 00:50
URI:	http://psaspb.upm.edu.my/id/eprint/2028

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