Antibacterial and cytotoxicity studies of some medicinal plants in Taman Botani, Universiti Putra Malaysia Bintulu Campus

Noor Hashim, Noor Haslinda (2007) Antibacterial and cytotoxicity studies of some medicinal plants in Taman Botani, Universiti Putra Malaysia Bintulu Campus. [Project Paper] (Submitted)

Text lp FSPM 2007 41.pdf Download (19MB)

Abstract

Extracts of ten medicinal plants were screened for their antibacterial properties and cytotoxicity activity. The antibacterial property was determined using Disc Diffusion Method against four test microorganisms, namely Escherichia coli, Pseudomonas aeruginosa, Listeria monocytogenes and Vibrio parahaemolyticus. These microorganisms were tested using concentration of plant extract ranging from 500 to 62.5 mg/mL. Of these, nine plant extracts showed varied levels of antibacterial activity. The greatest activity was exhibited by the methanolic extracts of Centella asiatica. C. asiatica extract inhibited all the bacteria strains whilst Vitex negundo extract presented a good activity against L. monocytogenes and V. parahaemolyticus and moderate activity against E. coli and Pseudomonas aeruginosa. Piper sarmentosum showed good activity against V. parahaemolyticus and moderate activity against other bacteria strains. Schefflera arboricola, Zingiber officinale, Orthosiphon aristatus and Gendarussa vulgaris extracts showed inhibition zone up to 125 mg/mL against selected bacteria. Stachytarphetajamacensis and Strobilanthes crispus extracts showed moderate activity against bacteria inhibition as they only inhibit at 250 mg/mL for selected bacteria. Pereskia bleo extracts showed no inhibition activity against all the bacteria strains. For cytotoxicity, the extract was assayed against Artemia salina by using Brine Shrimp Lethality Test method. Eight plant extracts presented strong activity against the brine shrimp viability. 0. aristatus showed high toxicity against brine shrimp because of high LCso value, 46.68 µg/mL. C. asiatica extract showed moderate activity and P. bleo showed low toxicity because of the LCso more than 250 µg/mL. Overall, C. asiatica showed high degree of antibacterial activity but not on cytotoxic activity. 0. aristatus presented high cytotoxic activity and moderate activity against bacteria strains. P. bleo however displayed low antibacterial activity as well as low cytotoxic activity.

Item Type:	Project Paper
Faculty:	Faculty of Agriculture and Food Sciences
Depositing User:	Mr. Azman Mohamad
Date Deposited:	17 Dec 2024 06:59
Last Modified:	17 Dec 2024 06:59
URI:	http://psaspb.upm.edu.my/id/eprint/2292

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