Risk assessment of genotoxic and carcinogenic estragole in plant food supplements (PFS) in Malaysia

Mohd Esa, Nur Syahirah (2019) Risk assessment of genotoxic and carcinogenic estragole in plant food supplements (PFS) in Malaysia. [Project Paper] (Submitted)

Text lp FPSK4 2019 29.pdf Download (22MB)

Abstract

Introduction: Plant Food Supplements (PPS) are commonly used by the consumers without knowing the actual ingredients in the PPS as they thought all "natural" ingredients are "safe". Estragole is among of genotoxic and carcinogenic alkenylbenzenes derivatives that can naturally be found in plant such as basil, fennel and anise. Objective: This study was conducted to determine the risk from exposure to estragole via consumption of PFS using margin of exposure (MOE) approach. Method: Ten local PFS were purposively purchased and the level of estragole in the samples was quantified using Ultra High-Performance Liquid Chromatography (UHPLC). MOE approach was applied to calculate the risk for both genotoxic and carcinogenic substance. The MOE was calculated by dividing the Benchmark dose level (BMDL10) to the estimated daily intake (EDI) of the PPS. Results and Discussions: Estragole was detected in all samples ranging between 3 71.8±275 .5 µgig to 1950.6± 1575 .4 µgig. The EDI values calculated were from 0.021 mg/kg bw/day to 0.117 mg/kg bw/day. All samples were found to have MOE less than 10,000 with minimum value of 20-60 and maximum value of 150-310 indicating high priority for risk management action. Conclusion: It is concluded that Malaysian populations are exposed to estragole via consumption of PFS and risk management actions are needed in order to control the exposure to this natural genotoxic and carcinogenic chemical. Keywords: estragole, plant food supplements (PFS), margin of exposure (MOE), risk assessment

Item Type:	Project Paper
Subjects:	R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	25 Feb 2026 01:34
Last Modified:	25 Feb 2026 01:34
URI:	http://psaspb.upm.edu.my/id/eprint/2731

Actions (login required)

View Item