Samsuri, Nur Ain (2019) Mutagenicity assessment of paddy water from Tanjung Karang, Selangor using Salmonella typhimurium TA 98 strain: a preliminary study. [Project Paper] (Submitted)
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Abstract
Introduction: Paddy plantation is one of the important agricultural activities because rice is a staple food in Malaysia. However, there is a possible exposure of mutagenic compounds to surface water via paddy plantation such as from heavy metals, pesticides, heterocyclic amines, and polycyclic aromatic hydrocarbons. This can cause a threat to the human health as the surface water are used as a primary source of drinking water, irrigation for agricultural purposes and other human activities. Objective: The study aimed to determine the mutagenic activities of paddy water at Tanjung Karang, Selangor by using Salmonella typhimurium TA 98 strain. Method: Ames test was chosen as it is widely used to screen a wide range of chemical substances that can produce genetic damage that leads to gene mutation. This study consists of three major methods which were sampling of water, solid phase extraction and Ames test. Firstly, the water was obtained from paddy field in Kampung Sawah Sempadan, Tanjung Karang at 9 respective sampling points. Next, solid phase extraction was conducted by using the 9 water samples to concentrate and purified the solution. Then, the concentrated solutions from solid phase extraction were exposed to the Salmonella typhimurium TA 98 strain in Ames test to evaluate the mutagenic activities. Result: From the result, it was found that there was mutagenic activity in 6 samples during sampling time 1 and 6 samples during sampling time 2. The positive samples were from inlets, points and also outlets of paddy blocks with a minimum total mean of 92 ± 87 revertants to maximum of 3 77 ± 222 revertants colonies per plate. Based on the statistical analysis, it was found that there was no significant difference in each paddy water samples in sampling time 1 and sampling time 2 and between the sampling time 1 and sampling time 2 since the p>0.05. Conclusion: It was concluded that there were positive mutagenic activities in some of the paddy field water samples from Tanjung Karang, Selangor. All in all, public need to be aware of the chemicals that they are using and exposed, to reduce the risk from the exposure to cancer agents. Keywords: Paddy water, mutagens, Ames test
| Item Type: | Project Paper |
|---|---|
| Subjects: | R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Faculty: | Faculty of Medicine and Health Science |
| Depositing User: | Ms Norafizah Radzuan |
| Date Deposited: | 25 Feb 2026 01:55 |
| Last Modified: | 25 Feb 2026 01:55 |
| URI: | http://psaspb.upm.edu.my/id/eprint/2733 |
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