Prevalence and pattern of renal osteodystrophy and its association factors among chronic dialysis patients in two-centers from March until June 2013

Abdullah, Noor Azira and Bacho, Siti Nadhrah (2013) Prevalence and pattern of renal osteodystrophy and its association factors among chronic dialysis patients in two-centers from March until June 2013. [Project Paper] (Submitted)

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Abstract

Introduction:Renal osteodystrophy is the skeletal complication of end-stage renal disease which is a multifactorial disorder of bone remodelling which affects almost all patients with advance chronic kidney disease (CKD). In Malaysia, the number of dialysis patients is increasing but little information is available about their bone disorders. Objectives: To describe the patterns of renal osteodystrophy and its association factors among chronic dialysis patients, and to compare the characteristics between hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) in two centers, Serdang Hospital and Kajang Hospital. Methods:We perfonned a cross sectional data collection, from medical records, for 281 patients doing maintenance dialysis in Serdang Hospital and Kajang Hospital. Patients who had undergone total parathyroidectomy were excluded from the study. Blood investigations were done for all patients from HD and CAPD unit from January 2013 till June 2013. These biochemical parameters were recorded and analyzed using SPSS, version 21. Intact Parathyroid Honnone (iPTH) values and Serum Alkaline Phospatase (ALP) were used to determine Turnover Bone Disease (TOBD). For iPTH<15Opg/ml and serum ALP <120 UIL classified as low bone turnover disease (LBTD), iPTH150-600 pg/ml and serum ALP 120-150 UIL as intennediate bone turnover disease (lBTD) and iPTH>600 pg/ml and serum ALP >150 UIL and as high bone turnover disease (HBm). Results:BothCAPD and HD had similar proportion of patients with corrected serum calcium-phosphate product less than 4.5 mmo121L2, which was 80% for CAPD and 82.2% for HD. HD had better phosphate control with 23.4% patients achieved the target compared with CAPD with 19%. In CAPD, LBTD and HBm had similar prevalence with 14.9% and 15.5% respectively. In HD, more patients were developed HBTD than LBTD with 29% vs 14%. There were no statistically significant associations between demographic characteristics (age, gender and ethnicity), dialysis duration, and co-morbidity status with pattern of renal osteodystrophy. Conclusion: HBTD was more prevalent in HD patients while the prevalence of both LBTD and HBTD were similar in CAPD patients. There are no associations between demographic factors, dialysis duration, and co-morbidity status with pattern of renal osteodystrophy. Keyword: Prevalence, renal osteodystrophy, Hemodialysis, Continuous Ambulatory Peritoneal Dialysis.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Adni Syuhaida Zon
Date Deposited:	22 Nov 2022 08:19
Last Modified:	21 Mar 2023 02:56
URI:	http://psaspb.upm.edu.my/id/eprint/279

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