The Effect of lithium carbonate on certain haematological and urine paramaters in Macaca fascicularis

Thuthan, T. Pandiyaraja (1987) The Effect of lithium carbonate on certain haematological and urine paramaters in Macaca fascicularis. [Project Paper] (Submitted)

Text lp FPV 1987 16.pdf Download (2MB)

Abstract

A group of 6 monkeys (Macaca fascicularis) were used to determine the effect of lithium carbonate on certain haematological and urine parameters. Two monkeys were given the drug orally and one intraperitoneally. Three monkeys were not treated and served as controls. Blood and urine samples were collected . The blood urea nitrogen (BUN) concentrations, packed cell volume (PCV), total and differential white blood cell (WBC) counts, red blood cell (RBC) counts, urine protein and creatinine concentrations, and urine protein-to-creatinine ratios were determined on these samples. Intraperitoneal lithium carbonate did not produce any specific pattern in urine protein-to-creatinine ratio, although there were marked elevations in BUN and urine creatinine concentrations. In contrast to the dogs, urine protein-to-creatinine ratio may not be useful parameter as an indicator of renal damage in monkeys. This experiment suggests that BUN concentration may still be a more accurate indicator of renal damage than the urine protein-to- creatinine ratio in monkeys. It was found that oral lithium carbonate increased circulating white blood cell counts especially neutrophils. Other haematological parameters did not show any observable change. It can be suggested that oral lithium carbonate may be used in alleviating neutropenic states in monkeys.

Item Type:	Project Paper
Subjects:	Q Science > QL Zoology
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. CHE WA ZAKARIA
Date Deposited:	04 Jun 2026 03:54
Last Modified:	04 Jun 2026 03:54
URI:	http://psaspb.upm.edu.my/id/eprint/2821

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