Blood cholinesterase levels and neurobehavioral performance among primary school children in Tanjung Karang, Selangor

Zainol Abidin, Khairul Nadiah (2014) Blood cholinesterase levels and neurobehavioral performance among primary school children in Tanjung Karang, Selangor. [Project Paper] (Submitted)

Text lp FPSK4 2014 10.pdf Download (29MB)

Abstract

Introduction: Organophosphate (OP) is a chemical pesticide widely used to protect agricultural commercial crops against diseases in Malaysia. The use of OP however has effects on human health. For instance, children would be vulnerable because their neumdevelopmcnt system is still developing. Acute exposure to OP can also cause inhibition of cholinestemse in the brain, neummuscular junction and peripheral nerves. Objective: The objective is to determine the association between blood cholinesterase level and the neumbehavioral performance among primary school children who live near paddy field. Methodology: The study was conducted at Tanjung Karang, Selangor. The random sampling method was used to select the respondents based on the inclusive criteria; healthy primary school children within the range of 10-1 1 of year with parental written permission. The total number of children who participated in the study was 1 14. A set of questionnaire items were used to obtain children background information and was filled up by their parents. Data was analyzed using descriptive analysis. Finger priek technique was used to collect blood samples of 0.0 lml. The blood cholinestemse level was examined using the rapid test cholinesterase test kit Model LOVIBOND 412870 AF287. All seven test of Neurobehavioral Core Test Battery (NCTB) were used to measure their neurobehavioral performance. Result: The findings indicate poor neurobehavioral function in term of motor steadiness (36.61), rapid coordination of eye and hand (46.17), attention or response speed (47.28): and perceptual motor speed (47.38). There was significant correlation between blood terase level with neurobehavioral performance tests using Trail Making Test (p=0.003) and Pursuit Aiming Test(p=<0.001). Trail Making Test was significantly related to playing near to the paddy field (p=0.039) and Time Reactioflovement Test related to housing area near to the paddy field (p=0.042). There is also significant relationship between blood cholinesterase level ulth housing area(p=<0.001) and frequency of playing near to the paddy field (p=0.039). Conclusion: Housing area influenced blood cholinesterase levels of the children living near paddy farms which then, significantly influenced the neurobehavioral performance especially on steadiness speed and accuracy. Besides the cholinesterase level, neurobehavioral performance was associated with the housing area located near to the paddy field and frequency of playing near paddy field. Keyword: Blood cholinesterase, neumbehavioral performance, and primary school children

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Adni Syuhaida Zon
Date Deposited:	23 Nov 2022 03:20
Last Modified:	21 Mar 2023 03:24
URI:	http://psaspb.upm.edu.my/id/eprint/368

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