Anti-inflammatory effect of semi-purified leaf extract of ficus deltoidea in acute and chronic inflamation

Razali, Mohd Hafiz (2010) Anti-inflammatory effect of semi-purified leaf extract of ficus deltoidea in acute and chronic inflamation. [Project Paper] (In Press)

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Abstract

Summary: Ficus deltoidea is an epiphytic shrub which is native widely distributed in several countries of the Southeast Asia. In Malaysia, it is commonly known as Mas Cotek, serapat angin, telinga buruk and other names. Different parts of the plant are used traditionally to treat various kinds of ailments. The fruits are chewed to relieve headache, toothache and cold; powdered root and leaves of the plant has been applied externally to wounds and sores and around the joints for relief of rheumatism. The objective of this study is to evaluate the anti-inflammatory effect of semi-purified leaf extract of Ficus deltoidea in acute inflammation and chronic inflammation. Fractionation of ethanol crude extract of Ficus deltoidea was carried out with hexane, ethyl acetate and water partition. Hypothesis of this experiment are the 3 partitions have different effectiveness compared to non steroidal anti inflammatory drugs. All of experimental animal used in this study are male Sprague Dawley (150-300g). Paw edema test was conducted acute inflammation. The negative control group (group 1) received 1 ml of 5% Tween 80, positive control groups received 10 mg/kg aspirin (group 2). Meanwhile for treatment groups, he rats received 150 mg/kg of partition extract respectively. For chronic inflammation test, the cotton pellet granuloma test was conducted containing 5 groups as above. Based on the result, Ethyl acetate partition showed the most significant reduction in acute inflammation whereas hexane partition showed the most significant reduction in chronic inflammation. All treatments showed significant difference (P<0.05) in reduction of paw volume when compared to the negative control group (5% Tween 80%). 150 mg/kg EAPT showed the best inhibitor with the progressing inhibition. Secondly is 150 mg/kg WPT which is better that positive control drug (10 mg/kg Aspirin). The least inhibition was HPT. The statistical result showed that all the treatments are significant compared to negative control 5% Tween 80. Based on result, 150 mg/kg HPT is the highest percentage of inhibition of both anti-transudative and anti-proliferative and 150 mg/kg WPT is second. Then, it is followed bu 10 mg/kg Aspirin and lastly 150 mg/kg EAPT. In conclusion, all partitions of Ficus deltoidea ethanol leaf extract have different effectiveness compared to non steroidal anti-inflammatory drugs (NSAIDs)

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	23 Nov 2022 03:46
Last Modified:	15 Feb 2023 00:44
URI:	http://psaspb.upm.edu.my/id/eprint/449

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