Association between glycaemic control and dyslipidaemia in type 2 diabetes patients in Hospital Putrajaya

Lee, Huey Ming and Muhamad, Mohd Azril (2013) Association between glycaemic control and dyslipidaemia in type 2 diabetes patients in Hospital Putrajaya. [Project Paper] (Submitted)

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Abstract

Background: The prevalence of diabetes mellitus (DM) in Malaysia is increasing drastically. Patients with diabetic dyslipidaemia are at a greater risk of developing cardiovascular disease. There is limited data on the association between glycated haemoglobin (HbA1c) and dyslipidaemia in type 2 DM (T2DM) patients in multiethnic Malaysian population. Aim: To determine the association between glycaemic control and dyslipidaemia in dyslipidaemic type 2 DM patients in Hospital Putrajaya. Methodology: This is a cross sectional study using retrospective data from January 2009 to December 2012 of 214 T2DM patients with dys1ipidaemia, carried out at the endocrine clinic, Hospital Putrajaya, a tertiary endocrine centre. Data was analysed using IBM SPSS Statistics version 21.0 for Windows. Results: FBG and HbA1c were significantly correlated with TC, TG, LDL, non-HDL, LDL/HDL ratio and TC/HDL ratio. The magnitude of correlation for all these lipid parameters was greater with HbA1c than FBG. The correlation coefficient of HbA1c was higher with TC/HDL ratio than other lipid parameters. The level of TC, TG, non-HDL and TC/HDL ratio were significantly higher in patients with HbA1c 2: 6.5% as compared to patients with HbA1c < 6.5%. In patients on statin treatment, non-HDL, LDL/HDL ratio, TC/HDL ratio and HbA1c were signifi.~antly lower than non-treated patients. Conclusion: The findings indicate significant association between glycaemic control and dyslipidaemia in T2DM. HbA1c can be used as a biomarker for dysllpidaemia in addition to glycaemic control and is a potential indirect marker of predicting CVD risk in T2DM patients. Key words: diabetic dyslipidaemia, glycated haemoglobin (HbA Ic), type 2 diabetes mellitus, lipid parameters,jasting blood glucose (FBG).

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Mr Muhamad Fazril Awang
Date Deposited:	23 Nov 2022 03:48
Last Modified:	23 Nov 2022 03:48
URI:	http://psaspb.upm.edu.my/id/eprint/463

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