Comparison of two different disinfectants in the inactivation of Newcastle disease virus and Infectious Bursal disease virus

Man, Maizatul Amirah (2017) Comparison of two different disinfectants in the inactivation of Newcastle disease virus and Infectious Bursal disease virus. [Project Paper] (Submitted)

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Abstract

The poultry industry is currently threatened by either endemic or emerging viral diseases associated with major economic losses to the industry. Chemical disinfectants may help in disrupting the transmission of viral pathogen; however many of these disinfectants could pose harmful effect to the farm workers due to its toxicity and corrosive rating. Hence, disinfectant that has less adverse health effect without compromising its efficacy need to be tested as potential alternative disinfectant. Silver nanoparticles have been studied mainly for their antimicrobial potential; however, it has also been proven to be effective against viruses. In this study, the virucidal efficacy of two nanosilver-based disinfectants, product A and product B were investigated against the Newcastle Disease Virus (NDV) and Infectious Bursal Disease Virus (IBDV). Quantitative analysis using embryonated eggs was used to determine the ability of these disinfectants to inactivate the viruses. Both disinfectants showed the ability to inactivate NDV in different concentrations. However, there was reduced efficacy of both disinfectants when tested against IBDV. Product A has greater virucidal efficacy against IBDV when using manufacturer’s recommended concentration compared to when using 3-fold diluted concentration. In contrast, Product B has lower virucidal efficacy compared to product A but the efficacy was comparable between the two concentrations tested. It was concluded that both disinfectants effectively inactivate enveloped virus compared to non-enveloped virus and their efficacies are concentration-dependent. As product A and product B showed virucidal efficacy against NDV and IBDV, the use of nanosilver-based disinfectant provides a less hazardous choice of disinfectant; however, the effective concentration need to be further evaluated based on its specific application in the poultry industry.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	08 Feb 2023 03:04
Last Modified:	08 Feb 2023 03:04
URI:	http://psaspb.upm.edu.my/id/eprint/731

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