A Systematic Review on Herbal Plants from Southeast Asia Reported to Possess Anti-Dengue Activity

SELVARAJA, LINESH KUMAR (2021) A Systematic Review on Herbal Plants from Southeast Asia Reported to Possess Anti-Dengue Activity. [Project Paper] (Submitted)

Text FPSK2 2021 1.pdf Download (1MB)

Abstract

Introduction: Dengue is one of the alarming diseases in Southeast Asian countries. The use of modern symptomatic medicines to eradicate them was found to be less efficient in overcoming increasing dengue cases. Objective: This systematic review was aimed to provide information such as the name of herbal plants, parts of herbal plants, active compounds present, type of extracts, assays and study design used, IC50/CC50/ LC50 values obtained from the herbal plants with anti-dengue properties studies in Southeast Asia and assess the risk of bias of the selected studies using low, medium and high risk. Methodology: This systematic review was done based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The data was collected from 11 eligible articles obtained from the electronic search (PubMed, Science Direct, Scopus and Wiley) from the year 2016–2021. The data were then analyzed using descriptive statistical methods in the Microsoft Excel Version 2013. Results: Thailand and Malaysia are the most prominent countries involved in anti-dengue herbal plants research followed by Vietnam and Indonesia. Some of the herbal plants from Genus Cinnamomum studied mostly among the selected articles on potential vector control agents. Most of the studies used leaf parts due to its medicinal properties. Flavonoids are active compounds commonly found in examined herbal plants as they possess significant anti-dengue properties. Most of the studies have been conducted from ethanol and methanol extract as compared to aqueous extract as it has the potential to yield high extraction of active compounds present in the leaf parts. Denv-2 protease inhibition assay, foci-forming unit assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay were the assays used in in-vitro studies and larvicidal bioassay was the assay used in the in-vivo studies. IC50 and CC50 values are measured in in-vitro studies and LC50 values are measured in in-vivo studies. Discussion: Some of the herbal plant species from Genus Cinnamomum possess anti-dengue activity for potential vector control agents. The leaf part of herbal plants using ethanol/methanol extract could be one of the suggestions to produce anti-dengue remedy and vector control agents. Moreover, it is recommended to choose herbal plants that contain flavonoids in high proportion. The type of assay used and the values of IC50/CC50/ LC50 measured will be based on the study design used. The percentage score for risk of bias assessment shows all the eligible 11 articles have low risk of biases. Conclusion: This review has provided some information on herbal plants in Southeast Asia with potential anti-dengue properties. Keywords: Dengue, Southeast Asia, Herbal plants, Systematic review

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	13 Feb 2023 04:03
Last Modified:	22 Aug 2023 07:50
URI:	http://psaspb.upm.edu.my/id/eprint/743

Actions (login required)

View Item