Correlation between the volume of mri brain infarct and inflammatory markers among acute ischemic stroke patients in HPUPM

Mohamad Ariff, Anna Maisarah and G. Baramesvaran, Tharani and Azmi, Muhammad Syakir (2021) Correlation between the volume of mri brain infarct and inflammatory markers among acute ischemic stroke patients in HPUPM. [Project Paper] (Submitted)

Text FPSK1 2021 31.pdf Download (3MB)

Abstract

Introduction: Stroke is one of the top five leading causes of death in Malaysia and increases in the mortality rate between 2016 and 2019. There is growing evidence that inflammation plays an important role in acute ischemic stroke. The level of inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are strongly correlated with the volume of brain infarct detected using Magnetic Resonance Imaging (MRI). These laboratory and radiological findings will eventually predict the mortality and recurrent vascular events in patients with acute ischemic stroke. Objective: This cross-sectional study conducted in Hospital Pengajar Universiti Putra Malaysia aims to determine the correlation between the volume of MRI brain infarct with inflammatory markers among patients with acute ischemic stroke in HPUPM. Methodology: Patients’ sociodemographic information and level of inflammatory markers were extracted from the Hospital Information System (eHIS), the MRI images were accessed through the Picture Archiving and Communication System (PACS) whereas the MRI reports for each sample were searched from the Reporting Information System (RIS). In addition, the MRI sequences DWI/ADC and FLAIR axial were selected. The findings of the site and size of brain ischemia were studied. Results: This study was based on 60 data sets of patients diagnosed with acute ischemic stroke in Hospital Pengajar Universiti Putra Malaysia, Serdang, Selangor. The majority of the patients were male (68.3%), Malay (51.7%) and ranging from age group 61-75 years old. Most underlying medical conditions recorded among the patients are hypertension (73.3%), dyslipidemia (50%) and diabetes mellitus (50%). Patients admitted to the hospital with markedly high CRP level. The ESR level was normal, the most recorded among the 28 AIS patients. Middle cerebral artery infarct was the most affected area among the patients (38.3%) and the mean volume of MRI brain infarction is 27.3268 土55.6957cm3. A statistically significant association was found between CRP and volume of brain infarction whereas no association was found between ESR and volume of brain infarction. Conclusion: A significant association was found between CRP and volume of brain infarction. No association was found between ESR and volume of brain infarction. Recommendation: We would like to suggest other researchers to involve larger sample sizes with longer duration and also include with another stroke medical centre in Malaysia Keywords: acute ischemic stroke, inflammatory maker, volume brain infarct, MRI

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	04 Sep 2023 06:45
Last Modified:	04 Sep 2023 06:45
URI:	http://psaspb.upm.edu.my/id/eprint/1032

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