Risk assessment of Aristolochic acids from traditional herbal medicine marketed in Malaysia using margin of exposure approach

ABDUL MANAF, NUR ATIQAH (2022) Risk assessment of Aristolochic acids from traditional herbal medicine marketed in Malaysia using margin of exposure approach. [Project Paper] (Submitted)

Text FPSK4 2022 39.pdf Download (1MB)

Abstract

Introduction: Aristolochic acid (AA) is a natural chemical that is abundant in Aristolochia plants. Herbal remedies containing Aristolochia species are believed to heal snake bites, increase breastfeeding and urination, and reduce edema. Some of the herbal medicines like slimming pills containing AA may induce kidney tumor. Objectives: The aim of this study was to assess the risk of AA from traditional herbal medicine marketed in Malaysia using the Margin of Exposure (MOE) approach. Methodology: A total of 31 samples of traditional herbal medicine suspected to contain AA were purchased via online or over the counter. Samples were extracted using the hot water extraction method and analyzed using Ultra Performance Liquid Chromatography. Then, an estimated daily intake (EDIs) value was calculated, and the risk was evaluated using the MOE approach. Results and Discussion: From 31 herbal medicine samples, two samples were found to contain aristolochic acids I ranging from 104.0 to 262.6 μg g-1. The EDIs obtained were ranging from 3.468 to 8.755 μg kg-1 bw-1 day-1. The MOEs calculated from exposure to AA from these traditional herbal medicines were below 10,000. Conclusion: The calculated MOE from traditional herbal medicines containing AA marketed in Malaysia were below 10,000 indicating the necessity for risk management action and causing public concern. Keywords: Risk assessment, Aristolochic acid, Margin of Exposure and Estimated Daily Intake

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Mr Hafizzuddin Hamidon
Date Deposited:	23 Aug 2023 02:12
Last Modified:	23 Aug 2023 02:12
URI:	http://psaspb.upm.edu.my/id/eprint/1167

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