Antinociceptive Activity of the Essential Oils of Zingiber officinale on Formalin Induced Paw Licking in Mice

Salleh, Mimi Athirah (2020) Antinociceptive Activity of the Essential Oils of Zingiber officinale on Formalin Induced Paw Licking in Mice. [Project Paper] (Submitted)

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Abstract

Zingiber officinale or locally known as ginger belongs to Zingiber genus as well as the family of Zingiberaceae. The origin of this plant is uncertain since it does not grow in the wild forest. It has been commonly used as a spice and herbal medicine for hundreds of years. It is also claimed to be useful in traditional medicinal practices in order to treat colds, headaches, nausea and emesis. Previously, studies of this plant reported that it has various medicinal properties including anti-inflammatory, antimicrobial, anticancer and antioxidant. Objective: This study generally aims to investigate the analgesic effects of essential oil of Zingiber officinale on formalin induced paw licking in mice. Hypothesis: It is hypothesized that formalin induced paw licking in mice can be inhibited by oral administration of essential oil of Zingiber officinale for nociception. Methodology: The rodent mice were pre-treated with different concentrations of essential oil of ginger (GEO) at 10, 30 and 100 mg/kg by oral administration for one hour. The mice were injected with 2.5% formalin subcutaneously into the plantar surface of one of hind paws after one hour. The observation of the paw licking of mice were comprised with two phases which phase 1 (early phase) at 0-5 minutes and phase 2 (late phase) at 15-30 minutes. Results: The three different concentrations at 10, 30 and 100 mg/kg of GEO significantly reduced the time spent of each mouse on licking and biting of the injected hind paw during the early/neurogenic phase by 27.82%, 29.75% and 35.21% as well as late/inflammatory phase by 37.92%, 43.42% and 60.91%. Conclusion: Based on the findings, the antinociceptive activity that produces by this plant is possibly by the constituents of numerous bioactive compounds of ginger in exhibiting various medicinal properties to treat a wide variety of ailments.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	22 Aug 2023 07:55
Last Modified:	22 Aug 2023 07:55
URI:	http://psaspb.upm.edu.my/id/eprint/1289

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