Anti-Inflammatory Effect of Zingiber Officinale Var Bentong Essential Oil in Mice Induced with Inflammation

Siti Nor Izzaty Rosli, Siti Nor Izzaty Rosli (2020) Anti-Inflammatory Effect of Zingiber Officinale Var Bentong Essential Oil in Mice Induced with Inflammation. [Project Paper] (Submitted)

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Abstract

Zingiber Officinale (Zingiberaceae) or “halia bentong” is a unique ginger species that can only be grown in Bentong district, Pahang because of its cold temperature and fertile soil. It is reported that the rhizome of Halia Bentong contains various active compounds that can exhibit medicinal properties including anti-diabetics, anti-inflammation, analgesic, antipyretic and anticancer activity. Inflammation is the condition in which the body responds to the harmful stimuli in preparation of bodily repair. Halia Bentong has been used traditionally in order to treat inflammation as it contains active ingredients such as gingerol that plays important roles in the inflammation. Objective: The aim of the study is to investigate the anti-inflammatory activity of Zingiber Officinale Rosc essential oil (GEO) against the acute model of the mice. Hypothesis: It is hypothesized that GEO will exhibit a significant effect of anti-inflammatory response in the acute inflammation model of mice. Methodology: The anti-inflammatory activity of the GEO is evaluated using an acute model of inflammation; carrageenan-induced paw edema test in male ICR mice. Different dosage of the GEO (10,30,100 mg/kg) was administered respectively into the mice orally. Then, the edema was induced by injecting the carrageenan at the left hind paw of the mice. The paw thickness of the mice was measured at (0,1,2,3,4 and 5 hour) using a digital Vernier caliper. The results of the experiment were analyzed using two-way ANOVA and Bonferroni’s test. Result: The two-way ANOVA revealed a significant effect of GEO treatment (p < 0.05) inhibition of paw edema. The GEO has shown significant inhibition of paw edema at the first phase which are at 1 and 2 hours after induction of oedema and second phase after 3,4 and 5 hours. Conclusion: The results of the study suggest that the GEO possess significant (p<0.05) anti-inflammatory potential justified by the traditional applications of ginger in treating diseases associated with inflammation.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	22 Aug 2023 07:57
Last Modified:	22 Aug 2023 07:57
URI:	http://psaspb.upm.edu.my/id/eprint/1315

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