Investigating the Effect of Mitragyna Speciosa Methanol Extraction on Rewarding Pathway in Brain of Sprague Dawley Rat

Ahat@Salim, Nurul Aqilah (2020) Investigating the Effect of Mitragyna Speciosa Methanol Extraction on Rewarding Pathway in Brain of Sprague Dawley Rat. [Project Paper] (Submitted)

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Abstract

Mitragyna speciosa, which is also commonly known as kratom in Thailand and ketum in Malaysia, is a native plant to Southeast Asia region especially, Thailand and Malaysia. This plant is used as to treat injury or illness and also it is known for its analgesic uses. Previous study had found that this Mitragyna speciosa has effect on brain which leads to hedonic consequences (reward). Dopamine is released from ventral tegmental area (VTA) and then being transmitted to ventral striatum. Increase in dopamine may lead to an addiction of herbs or drugs that caused such consequences. Objectives: This study generally aims to investigate the effect of Mitragyna speciosa methanol extraction on rewarding pathway in Sprague Dawley rat brain. Hypothesis: This Mitragyna speciosa methanol extraction will lead to increment of dopamine in rat brain, particularly on rewarding pathway in the rat brain for both acute and chronic administration of the extracts. Methodology: Extracted M. speciosa will be administered to two big groups of rat which are first group for sub-acute study and second group is for chronic study. In each group, there would be 5 sub-groups which are administration of positive control, negative control, low, medium and high concentration of extracted M.speciosa. The period of sub-acute study is up to seven days and for chronic study it is up to twenty one days. Results: The increment of dopamine level in striatum and prefrontal cortex can be seen clearly after the administration of M. speciosa extracts. Conclusion: Mitragyna speciosa does affect the rat brain particularly in rewarding pathway in which more dopamine is released in the brain to lead to hedonic consequences.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Nor Safa'aton Saidin
Date Deposited:	23 Aug 2023 00:06
Last Modified:	23 Aug 2023 00:06
URI:	http://psaspb.upm.edu.my/id/eprint/1316

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