Immunophenotyping analysis in patient suspected with multiple myeloma at Hospital Kuala Lumpur from year 2011 to 2012

Adenan, Noor Amira Asnida and Chen, Jun Jie (2013) Immunophenotyping analysis in patient suspected with multiple myeloma at Hospital Kuala Lumpur from year 2011 to 2012. [Project Paper] (Submitted)

Text FPSK1 2013 31-.pdf Download (24MB)

Abstract

INTRODUCTION: Multiple myeloma is a cancer of plasma cells. Current diagnosis criteria required morphological assessment of plasma cell percentage. Flowcytometryimmunophenotyping is a newer and additional method for diagnosis of multiple myeloma and other plasma cell disorder. OBJECTIVE: This study aim to determine the type and frequency of antigen expression by flow cytometry in patients presumed with multiple myeloma and correlates its with patient sociodemographic and clinical presentations at diagnosis. METHODOLOGY: This was a retrospective,cross-sectional study conducted in Kuala Lumpur Hospital from 25th March 2013 till 5thSeptember 2013. Standardized proforma were used to extract secondary data from immunophenotyping reports from laboratory haematology of Kuala Lumpur Hospital. RESULTS:A total of 141 patients were included in this study. The age was range 19-55 years old. There were 82 male patients as compare to 59 female.Majority of them were Malays(55.3%) followed by Chinese (29.8%) and Indian(9.9%). Anaemia was the common presentations (57.4%). Analysis showed more than half of patients had aberrant antigen expression of CD33, CD56 and CD117 comprise of 14.2%, 59.6% and 37.8%, and respectively. There was a significant association between gender and CD33 and CD56 antigen expression ofp=0.027,p= 0.020 respectively. CONCLUSION:This study highlights the role of flowcytometry in providing a rapid and accurate result in addition to classical methods used in determining diagnosis and prognosis of patients with presumed multiple myeloma. However, further studies are needed to collaborate the relationship between FCM immunophenotype with the underlying genetic alterations. KEYWORDS:immunophenotyping, multiple myeloma, antigen expression.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	21 Nov 2022 07:47
Last Modified:	16 Feb 2023 03:41
URI:	http://psaspb.upm.edu.my/id/eprint/132

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