Mohamad Saat, Nuril (2022) Evaluation of Anti-psoriatic Activities of Sweet Potato (Ipomoea batatas) Leaf Ethanolic Extract on Imiquimod-Induced Psoriasis-like Dermatitis in Sprague Dawley Rats. [Project Paper] (Submitted)
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Abstract
Psoriasis is an inflammatory disease that is caused by a dysfunctional immune system, which the body mistakenly initiates an inflammatory response. It is marked by a significant proliferation of keratinocytes in the epidermis of the patient. Psoriasis is characterized by well-defined plaques or papules with silver scales. Individuals with psoriasis may have significant physical discomfort, depending on the degree of their condition. Ipomoea batatas (I. batatas) leaf ethanolic extract (IBLE) has been discovered to contain various beneficial bioactive compounds such as polyphenols and flavonoids that contribute to anti-inflammation activity. These properties have been associated with anti-inflammatory effects by neutralizing free radicals that can possibly damage the cells. Objective: This study investigated the anti-psoriatic effects of IBLE on the IMQ-induced psoriasis-like dermatitis in Sprague Dawley (SD) rats. Methodology: Thirty-six male SD rats were randomly divided into 6 groups (n=6): Normal control (Group 1), Negative control (Imiquimod, IMQ; 62.5mg/rat) (Group 2), Positive control (clobetasol propionate; 25mg/kg BW) (Group 3), IBLE 1% (Group 4), IBLE 5% (Group 5) and IBLE 10% (Group 6). Phenotypical observations on the dorsal skin in term of redness, thickness and scaling were recorded and PASI scoring were conducted daily from day 1 up to the end of the study, day 21. Results: Results obtained from this study have demonstrated that the ethanolic extract of I. batatas leaf (IBLE) at 5% and 10% was able to significantly (p<0.05) ameliorate the development of psoriasis-like dermatitis by lowering the degree of PASI score of IMQ-induced psoriasis-like dermatitis in IBLE-treated rats as compared to the non-treated groups. Discussion: Various phytochemical studies have reported that sweet potato leaf extract contains a high content of polyphenolic compounds. Polyphenolic compounds, which are known for their strong antioxidative, and anti-inflammatory properties, might be responsible for the anti-psoriatic effects of IBLE, possibly by scavenging and neutralizing the free radicals. Conclusion: Findings from this study suggest that the ethanolic extract of I. batatas leaf (IBLE) has the potential to be developed as an alternative therapeutic strategy for psoriasis treatment. Further study needs to be done to understand the mechanism of action of IBLE underlying its anti-psoriatic effect.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Medicine and Health Science |
| Depositing User: | Ms. Nor Safa'aton Saidin |
| Date Deposited: | 22 Aug 2023 06:35 |
| Last Modified: | 22 Aug 2023 06:35 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1395 |
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