Yang, Xingyu (2022) Insulin Resistance and Deficiency: Potential Mechanisms Linking Type 2 Diabetes Mellitus and Its Related Conditions to Alzheimer’s Disease: Systematic Review & Bibliometric Analysis. [Project Paper] (Submitted)
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Abstract
Numerous epidemiological studies have shown a clear association between Type 2 diabetes (T2DM) and a cognitive impairment predisposes to neurodegeneration, particularly in Alzheimer’s Disease (AD). There is a rapid growth in the literature pointing toward insulin deficiency and insulin resistance as mediators of AD. Unfortunately, molecular and pathophysiological mechanisms that underlie AD still have many dark sides. Justification: Therefore, Systematic reviews and Geometry Network software were deployed in this study to analyze the keyword findings with the algorithm assessment to ascertain the correlation between T2DM and AD markers based on the total number of epidemiological studies between 2010 - 2021. Objectives: This study focuses on the insulin signaling markers in T2DM patients linked to AD establishment and identifying the eligible studies on insulin signaling in T2DM patients with the pathophysiology of AD. Methodology: A search strategy was developed by conducting a word frequency analysis on potentially relevant articles using the Systematic Review Accelerator (SRA) using Word Frequency Analyser to determine the key terms. For inclusion criteria, studies involved diabetic patients (>35 y/o) with other diseases such as cardiovascular disease, hyperlipidemia, hypertension, and kidney disease. Patients with gestational diabetes mellitus (GDM) and other neurodegenerative diseases such as ataxia, Amyotrophic Lateral Sclerosis (ALS), and Parkinson's Disease were excluded. Information sources were across PubMed, Scopus, Cochrane CENTRAL, Science Direct, and was conducted forward and backward citation between the years 2010 –2021. The risk of bias was assessed using the Cochrane Risk of Bias tool assisted by RobotReviewer. Lastly, VOSviewer is a software tool for constructing and visualizing a bibliometric network. Conclusion: A higher association between T2DM and neurodegeneration was discovered from the current systematic review of epidemiological studies, which supports the in-vitro and in-vivo investigations and presented in illustrated diagram. It can be concluded that impaired insulin signaling is strongly linked to multifaceted pathways that can exacerbate neurodegeneration.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Medicine and Health Science |
| Depositing User: | Ms. Nor Safa'aton Saidin |
| Date Deposited: | 22 Aug 2023 07:05 |
| Last Modified: | 22 Aug 2023 07:05 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1399 |
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