Thiourea compound as an alternative treatment for sporotrichosis

Ragu, Thusahtani (2020) Thiourea compound as an alternative treatment for sporotrichosis. [Project Paper] (Submitted)

Text lp FPV 2020 7.pdf Download (1MB)

Abstract

Thioureas play a significant role in medicinal chemistry and agriculture due to their biological activities such as antibacterial, antifungal, antiviral, herbicides, rodenticides, phenoloxidase enzymatic inhibitors, anti-HIV and anti-tumor agents. Three types of benzoylthiourea derivatives; benzoylglycine, benzoylsarcocine and benzoyldiethanol were screened for their potential antifungal activity against Sporothrix schenckii. Disc diffusion method was used to detect the presence of zone of inhibition followed by broth microdilution to determine minimum inhibitory concentration (MIC). The antifungal effects to S. schenckii were further assessed by inoculating onto Sabouraud Dextrose Agar (SDA) to determine the minimum fungicidal (MFC). There was no presence of zone of inhibition by all three benzoyl-thiourea. All compounds showed no antifungal activity since the diameter of inhibition zone measure was less than positive control inhibition zone. The MIC and MFC for benzoylglycine, benzoylsarcocine and benzoyldiethanol against S. schenckii were >0.0004M which was the highest concentration that was used in this experiment. The study demonstrated that benzoylglycine, benzoylsarcocine and benzoyldiethanol, with concentrations within 0.0004M – 0.00005M did not possess antifungal properties against S. schenckii.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	18 Oct 2023 04:27
Last Modified:	18 Oct 2023 04:27
URI:	http://psaspb.upm.edu.my/id/eprint/1449

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