Wong, Wei Shann (2020) Effect of ‘new age’ music on wound healing in ICR mice. [Project Paper] (Submitted)
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Abstract
Music intervention has been an increasingly popular form of treatment and therapy due to its low cost, easy application as well as its lack of side effects. Many researchers have proven its benefits in immunological function, behavioural changes, physiological changes and neurological function of the brain. This study was done to determine whether the use of ‘New Age’ music would help accelerate wound healing in ICR mice. Both groups were in-flicted with wounds using a 5mm dermal punch on the dorsal skin of the mice prior to the start of the experiment. Group 1 (G1; n=9) was exposed to Steven Halpern’s Deep Bamboo as treatment twice a day at 8 a. m and 8 p. m for two hours per day for 14 days whereas Group 2 (G2; n=9) was not exposed to any music as treatment and act as a negative control. Three mice from each group were euthanized on day 0, 7 and 14 at which the gross lesion and the skin tissue samples were collected for histopathology. For gross lesion, wound scor-ing and percentage of wound size reduction were calculated. As for histology, semi-quantitative scoring was done to evaluate wound healing, and quantitative scoring was done to evaluate the collagen density using pixel calculation. From the gross lesion wound meas-urement, it was noted that no significant (p>0.05) difference between the two groups on all three sampling days. In general, the percentage of wound reduction in the two groups were 0% for day 0, 40 – 75% for day 7 and 40 – 97.5% on day 14. Similarly, there is no significant (p>0.05) difference between the two groups on all sampling days for gross lesion scoring. Histological lesion scoring of area of lesion, immature granulation, mature granulation, re-epithelization and fibrosis between the two groups did not show significant (p>0.05) differ-ence between the two groups. In both groups immature granulation predominates on day 7, while re-epithelization and fibrosis were prominent in day 14. The number of collagen pixels in the two groups were insignificant (p>0.05) on all sampling days. This study suggests that application of ‘New Age’ music is ineffective in accelerating wound healing in mice.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Veterinary Medicine |
| Depositing User: | Ms. Nordeena Abdul Aziz |
| Date Deposited: | 19 Oct 2023 06:41 |
| Last Modified: | 19 Oct 2023 06:41 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1482 |
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