Lokman, Nurul Afiqah (2021) Cassia alata antifungal properties: a systematic review. [Project Paper] (Submitted)
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Abstract
Cassia alata (ringworm bush) is widely used in traditional medicine for its antifungal properties. This ornamental shrub often thrives in the humid conditions of the tropics. The applications of Cassia a/ata (C. a/ata) antifungal properties in veterinary medicine are systematically reviewed. This review was conducted in accordance to the Preferred Reporting Items for Systematic Review and Meta- analysis (PRISMA) study protocol. A literature search was performed by identifying all journal articles that are related to the topic from 3 databases, namely Scopus, Science Direct and CAB Direct. A total of 313 articles published from 2000 to 2021 were selected. Abstracts and references of these articles were later exported to EndNote X9 for further scrutiny. Following the screening and eligibility process, 30 studies were found to be eligible, and all relevant data was tabulated using Microsoft Office Excel 2016. A comprehensive review of the articles indicated that the most frequently used parts of the plant are the leaves, followed by flowers, roots, bark, and seeds. Organic extracts (e.g.: methanol and ethanol) were found to exhibit higher antifungal activity than other solvents. The antifungal effect of C. a/ata was mostly experimented on Candida albicans and Trichophyton mentagrophytes. The antifungal activity exhibited by C. alata extracts was equally effective against dermatophytes and yeasts. However, there were variations in the effectiveness of C. a/ata antlfungal activities reported. The discrepancy in the effectiveness of this plant in the in vitro studies may be due to the variation in conditions ofthe study and/orthe concentrations of crude extracts used. Therefore, determination of the exact phytochemical compound(s) responsible for the antifungal effect of C. alata in vitro is warranted. Nevertheless, the use of C. alata capped metal nanoparticles as an antifungal agent to overcome antimicrobial resistance seems promising at the moment.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Veterinary Medicine |
| Depositing User: | Ms. Nordeena Abdul Aziz |
| Date Deposited: | 14 Nov 2023 01:49 |
| Last Modified: | 14 Nov 2023 01:49 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1534 |
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