Che Ruslay, Siti Maryam (2023) Occurrence of low molecular weight polycyclic aromatic hydrocarbons (PAHs) in blood serums of adults living in different traffic volume areas in Klang Valley. [Project Paper] (Submitted)
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Abstract
Introduction: This study investigates the occurrence of low molecular weight polycyclic aromatic hydrocarbons (LMW-PAHs) among adults in low and high traffic volume areas. Presently, there is a lack of research in Malaysia that focus on specific molecular weight compound of PAHs in human blood. Objectives: This study aimed to compare the concentration of low molecular weight polycyclic aromatic hydrocarbons (LMW-PAHs) in blood serums of adult population living in high traffic volume area and low traffic volume area in Klang Valley, Malaysia and to determine its contributing factors of exposure. Methodology: Data on sociodemographic and exposure to PAHs were collected using questionnaire. A total of 203 respondents were involved in this study; 101 exposed group and 102 comparative group. Blood serum samples were extracted using ultrasonication, cleaned-up with solid phase extraction (SPE), quantified by gas chromatography mass spectrometry (GC-MS) to obtain the reading of the concentration of LMW-PAHs compounds. Results and Discussion: The findings from Mann-Whitney U test showed that the concentrations of LMW-PAHs in blood serums were significant different between the exposed group and comparative group (p<0.05). The median concentrations of LMW-PAHs in blood serums of exposed group were significantly higher than comparative group. The median concentrations of naphthalene, acenaphthene, acenaphthylene, fluorene, phenanthrene and anthracene in exposed group were 11.16 ng/mL, 2.56 ng/mL, 13.44 ng/mL, 8.54 ng/mL, 3.85 ng/mL and 4.52 ng/mL respectively. While the median concentrations of naphthalene, acenaphthene, acenaphthylene, fluorene, phenanthrene and anthracene in comparative group were 4.99 ng/mL, 9.45 ng/mL, 4.78 ng/mL, 1.43 ng/mL and less than detection limit respectively. The concentrations of naphthalene, fluorene, and anthracene were significant different between respondents with exposure to chemical in working environment and respondents without exposure to chemical in working environment (p<0.05). There were significant differences (p<0.05) between the concentrations of LMW-PAHs in blood serums and the home environment factors; (i) with and without traffic congestion, (ii) with and without open burning activities, (iii) with and without highway near residential area. Meanwhile, there were significant differences (p<0.05) between the concentration of phenanthrene and the status of passive smoker. There were significant differences (p<0.05) between (i) the vi concentrations of all target compounds in blood serum and the mode of transportation (ii) the concentrations of acenaphthene, fluorene, and anthracene and diet (eating grilled food) (iii) the concentrations of fluorene, phenanthrene, and anthracene with indoor and outdoor hobbies. Conclusion: The concentration of LMW-PAHs in blood serums of exposed group was significantly higher than comparative group. This study suggested the concentrations of LMW-PAHs in blood serums of respondents could be associated with factors such as exposure to traffic congestion, existence of highway near residential area transportation mode and open burning activities. Keywords: Polycyclic aromatic hydrocarbons (PAHs), blood serums, GC-MS, LMW-PAHs, extraction
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Medicine and Health Science |
| Depositing User: | Ms Norafizah Radzuan |
| Date Deposited: | 08 May 2024 04:52 |
| Last Modified: | 08 May 2024 04:52 |
| URI: | http://psaspb.upm.edu.my/id/eprint/1695 |
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