Occurrence of medium molecular weight polycyclic aromatic hydrocarbons (MMW-PAHS) in blood serums of adults living in different traffic volume areas in Klang Valley

Mustapa Kamal, Aina Basyirah (2023) Occurrence of medium molecular weight polycyclic aromatic hydrocarbons (MMW-PAHS) in blood serums of adults living in different traffic volume areas in Klang Valley. [Project Paper] (Submitted)

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Abstract

Introduction: The source of polycyclic aromatic hydrocarbons (PAHs) can be categorised into two which is from natural sources and anthropogenic (man-made) sources. From the natural sources, PAHs was released to the atmosphere via seepage of petroleum or natural gases and volcanic activities. The main source of PAHs that released into the atmosphere are from incomplete combustion of organic materials mainly derived from vehicular emission. Objectives: This study aims to compare the concentration of medium molecular weight of polycyclic aromatic hydrocarbons (MMW-PAHs) in blood serum samples of adults living in the highest and lowest traffic volume area in Klang Valley and associate the concentration of MMW-PAHs with the contributing factors (working environment, home environment and lifestyle). Methodology: Respondents that meet the criteria for this study were administered with questionnaire to obtain information on demographic and exposure of PAHs. A total of 203 of blood serum samples (101 exposed group and 102 comparative group) were collected among 203 individuals who were volunteered to participated in this study. Blood samples were extracted using solid-phase extraction (SPE) before injected into gas chromatography mass-spectrometry (GC-MS). Results and Discussion: The results showed that the concentration of fluoranthene (median=20.71 ng/mL, p<0.05), benzo(a)anthracene (median=7.56 ng/mL, p<0.05) and chrysene (median=8.25 ng/mL, p<0.05) were significantly higher in exposed group than comparative group (median fluoranthene=10.65 ng/mL; median benzo(a)anthracene=3.67 ng/mL; median chrysene=2.89 ng/mL). Respondents that exposed to chemical in working environment showed significantly higher concentration of fluoranthene, benzo(a)anthracene and chrysene (p<0.05) than comparative respondents. The serum concentration of fluoranthene, benzo(a)anthracene and chrysene were significantly different in (i) passive and nonpassive smokers, (ii) with and without highway near home environment, (iii) with and without traffic congestion near home environment and (iv) with and without open burning activities near home environment among all respondents (p<0.05). Fluoranthene and chrysene were found significantly different in respondent with indoor and outdoor hobbies (p<0.05). Conclusion: This study showed that the occurrence of PAHs in serums was significantly different among adults living high and low traffic volume areas. Besides that, the condition of traffic areas near home environment, diet intake, open burning activities, exposure to cigarette smoke, indoor/outdoor hobbies, exposure to chemicals in working environment were contributing factors to have greater concentration of PAHs in human. Keywords: Medium molecular weight of polycyclic aromatic hydrocarbons (MMW-PAHs), blood serum, gas chromatography mass-spectrometry (GC-MS), solid phase extraction (SPE), traffic

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	17 Apr 2024 08:10
Last Modified:	17 Apr 2024 08:10
URI:	http://psaspb.upm.edu.my/id/eprint/1711

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