In vitro study of basil seed oil with amoxicillin against staphylococcus aureus

Wahid, Muhammad Amir Asyraf (2022) In vitro study of basil seed oil with amoxicillin against staphylococcus aureus. [Project Paper] (Submitted)

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Abstract

Combination therapy has been used in the recent years among antibiotics, but the use of combination of antibiotic with medicinal plants are yet to be seen. The combination therapy between antibiotic and medicinal plants has great potential. The aim of the current study was to determine the antimicrobial potential and synergistic effect of basil seed when combined with Amoxicillin trihydrate against Staphylococcus aureus ATCC 25923. The plant oil was screened for its antimicrobial activity using disc diffusion method. The Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) were assessed using broth microdilution method. Basil seed oil exhibited antimicrobial activity to S. aureus. The MIC value of basil seed oil was 25% while MBC value was 50%. The synergistic effects of basil seed oil were observed in the combination with amoxicillin trihydrate. The inhibition zones were significantly increased in combination of plant oil with amoxicillin trihydrate (P<0.05). The percentage increase of inhibition zones between combination of basil seed oil with amoxicillin trihydrate was 44.71%. In conclusion, there is high antimicrobial potential of basil seed oil, and it has synergistic effect with antibiotic tested. The synergistic effect from the combination of basil seed oil and antibiotic may offer alterative of combination therapy against S. aureus infection.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	30 Apr 2024 03:07
Last Modified:	30 Apr 2024 03:07
URI:	http://psaspb.upm.edu.my/id/eprint/1725

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