Comparison between injectable toltrazuril-gleptoferron and oral toltrazuril with injectable iron dextran in the prevention of swine neonatal coccidiosis and iron deficiency anaemia

Koh, Hao Jie (2022) Comparison between injectable toltrazuril-gleptoferron and oral toltrazuril with injectable iron dextran in the prevention of swine neonatal coccidiosis and iron deficiency anaemia. [Project Paper] (Submitted)

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Abstract

Swine neonatal coccidiosis is an endemic and ubiquitous disease which caused by Cystoisospora suis. Iron deficiency anaemia (IDA) occurs in piglets because they are born with limited iron storage in the body. Both conditions cause retarded growth, which leads to significant economic losses to the farmers. This study aims to compare the effects between injectable toltrazuril-gleptoferron (ITG) and oral toltrazuril with injectable iron dextran (OTI) for the prevention of swine neonatal coccidiosis and IDA. Piglets from 15 sows in OTI group received an oral dose of toltrazuril (20 mg/kg) and a single intramuscular injection of iron (200 mg/piglet) 24 hours after parturition, while piglets from 15 sows in ITG group received intramuscular injection of ITG (45 mg toltrazuril + 200 mg gleptoferron) 24 hours after parturition. 3 piglets from each sow (total 90 piglets, 45 for each group) were randomly selected for sampling. Oocyst count (OPG), diarrhoea percentage, faecal score, blood haemoglobin level, and performance parameters were observed for 26 days and analyzed using Independent Student T-Test and Mann-Whitney U Test. The ITG group showed a trend of lower oocyst count and diarrhea percentage, better fecal scoring with no F4 score, no anemic piglets at weaning and better performance parameters. However, there are no significant differences (p > 0.05) between both groups. The single injectable toltrazuril and gleptoferron combination provide effective metaphylactic therapy as an alternative to prevent swine neonatal coccidiosis and iron deficiency anaemia in neonatal piglets, with the benefits of reduced labour intensiveness and stressful handling interventions.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	30 May 2024 08:03
Last Modified:	30 May 2024 08:03
URI:	http://psaspb.upm.edu.my/id/eprint/1858

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