Health risk assessment of food products containing aflatoxin using margin of exposure approach

Azmin, Nur Nabila (2023) Health risk assessment of food products containing aflatoxin using margin of exposure approach. [Project Paper] (Submitted)

Text 203878 NUR NABILA AZMIN lp FPSK4 2023 50.pdf Download (1MB)

Abstract

Introduction: Aflatoxin is one of the mycotoxins that are produced by moulds and the most common type of aflatoxin present is aflatoxin B1. The increasing favorability condition for mould growth and overconsumption of food products prone to aflatoxin contamination increases the risk of hepatotoxicity and liver cancer. Objectives: The objective of the study is to determine the risk of aflatoxin in food products from various countries in Asia using margin of exposure approach. This study evaluates the level of aflatoxin present, the estimated daily intake (EDI) and finally assess the risk of aflatoxin in food products. Methodology: The data used in this study were retrieved from published articles. The articles were collected from different studies originated from Asian countries from the year 2018 to 2022 that met the inclusion and exclusion criteria. The searching strategy used were using Boolean Operator. The exposure level towards aflatoxin were obtained for each food sample and estimated daily intake value was calculated. Finally, the margin of exposure value was calculated to assess the risk. Results and Discussion: A total of 563 records were obtained from the first search using the keywords and search string from PubMed and ScienceDirect respectively. A total of 159 records were removed due to duplicates, and more were removed due to ineligibility. The mean level of aflatoxin B1 detected from different food products ranging between 0.02μg/kg to 428μg/kg where maize samples from Indonesia records the highest level of aflatoxin B1, as maize are one of the food products that are most likely to be contaminated by aflatoxin. The range of an EDI of the samples is between 0.00001μg/kg bw/day to 44.703μg/kg bw/day where peanut samples from China records the highest EDI value which shows that peanuts are highly consumed by the population. The margin of exposure value calculated ranging from 1 to 122177. Values that were more than 10,000 indicates there is no priority for risk assessment while values that are less than 10,000 shows that there is high priority for risk assessment. About 88.78% of positive samples showed value less than 10,000, hence the exposure of the food products should be managed to avoid overexposure to food contaminated by aflatoxin. Conclusion: As conclusion, most of positive samples were found to be lower than 10, 000 indicating the priority for risk management action. There are few factors that may cause aflatoxin contamination such as improper management during plantation, poor transportation, and storage. The environmental factors such as favourable temperature and humidity may also cause aflatoxin contamination. Proper risk management steps should be taken to reduce the risk by reducing the exposure. Keywords: Health risk assessment, aflatoxin, estimated daily intake, margin of exposure, food products

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	13 Jun 2024 07:39
Last Modified:	13 Jun 2024 07:39
URI:	http://psaspb.upm.edu.my/id/eprint/1869

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