Risk assessment of estragole in plant food supplements using margin of exposure approach

A Razak, Nur 'Amirah (2018) Risk assessment of estragole in plant food supplements using margin of exposure approach. [Project Paper] (Submitted)

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Abstract

Plant food supplements (PFS) are commonly used by the consumers without knowing the actual ingredients in the PFS and they thought that all "natural" ingredients are "safe". Estragole is one of alkenylbenzenes constituent that is a genotoxic and carcinogenic compound that is naturally exist in plant such as basil, fennel and anise. Objective: This study was conducted to determine the risk from exposure to estragole via consumption of PFS using margin of exposure (MOE) approach. Method: Ten local PFS were purposively purchased and the level of estragole in the samples was quantified using Ultra High Performance Liquid Chromatography (UHPLC). MOE approach was applied to calculate the risk for both genotoxic and carcinogenic substance as suggested by European Food Safety Authority. The MOE was calculated by dividing the Benchmark dose level (BMDL10) to the estimated daily intake (EDI) of the PFS. Results and Discussions: Estragole was detected in all samples ranging between 113.5±63.3 to 378.7±221 mglg. The EDI values were calculated ranging from 1.11 x 104 to 3.36 x 10·3 mg/kg bw/day. Five samples were found to have MOE less than 10,000 (60% of recovery) while only three samples were found to have MOE less than 10,000 ( 100% of recovery) indicating the priority for risk management action. All of these samples are in paste forms and the EDI of the estragole in paste forms are higher compared to capsule form. The calculated MOE reflected a priority for risk management action, however it does not provide a quantitative estimate of risk. Conclusion: It is concluded that Malaysian populations are exposed to estragole via consumption of PFS and risk management actions are needed in order to control the exposure to this natural genotoxic and carcinogenic chemical. Keywords: estragole, plant food supplements, margin of exposure, estimated daily intake

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	14 Jun 2024 02:58
Last Modified:	14 Jun 2024 02:58
URI:	http://psaspb.upm.edu.my/id/eprint/1883

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