The effectiveness of telmisartan in management of cats diagnosed with chronic kidney disease

Lim, Joyce Qi Yi (2022) The effectiveness of telmisartan in management of cats diagnosed with chronic kidney disease. [Project Paper] (Submitted)

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Abstract

Chronic kidney disease (CKD) is a progressive disease, most commonly diagnosed in geriatric cats, as a result of lower glomerular filtration rate and, subsequently kidney failure. This study: 1) evaluated the effect of telmisartan on serum creatinine level, urine protein: creatinine (UP/C) ratio, systolic blood pressure (SBP), body condition score (BCS) and body weight (BW) in CKD cats, and 2) identified the correlation between UP/C ratio to BW and BCS of CKD cats treated with telmisartan. Medical records of 48 cats diagnosed with CKD treated with telmisartan were retrieved. Clinical parameters (serum creatinine level, UP/C ratio, SBP, BCS and BW) on Day-0 (pre-treatment) and posttelmisartan treatment at Day-14, -30 and -60 were descriptively analysed. Friedman’s testwas used to determine significant difference of parameters between time points whereas Wilcoxon test was used to identify the most significant changes at each time point compared to Day-0. The correlation of UP/C ratio to BW and BCS of the patients was determined using Spearman’s rho test. Telmisartan significantly (p<0.05) reduced the level of serum creatinine to normal at Day-60, reduced the UP/C ratio at Day-14, normalised the SBP at Day-60 and improved the BCS at Day-30. However, the BW was not significantly improved (p>0.05) over the period of 60 days observation. The UP/C ratio was negatively correlated to BW and BCS, (p<0.05) respectively. It was noted that all the patients’ conditions improved with better appetite despite having CKD. In conclusion, telmisartan effectively controls proteinuria in cats with CKD, indicated by clinical parameters: reduction in serum creatinine, normalised SBP, improved BCS and maintenance of BW.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms Nurhaznita Mahmood
Date Deposited:	31 May 2024 08:23
Last Modified:	31 May 2024 08:23
URI:	http://psaspb.upm.edu.my/id/eprint/1915

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