Histopathological findings of parasite in rattus Rattus captured in Klang Valley

Mohamad Aidil, Nur Adlina (2023) Histopathological findings of parasite in rattus Rattus captured in Klang Valley. [Project Paper] (Submitted)

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Abstract

Rattus rattus (R. rattus) is listed as one of the worst invasive species which colonise human settlements and has great resistance to parasitic infection, making them an excellent reservoir for zoonotic diseases. Surveillance of parasitic infections should be done regularly to prevent disease outbreaks. This study aims to observe pathological lesions exhibited by parasites among R. rattus in Klang Valley areas. In this study, a total of 25 R. rattus archived samples of pre-fixed 10% buffered formalin organs (liver, intestine, muscle, brain, heart, spleen, kidney, and lung) tissues were processed for Haematoxylin and Eosin staining. Histopathological examination under a light microscope at 4X, 10X, and 20X magnifications was conducted. There were 7 tissue and intestinal parasites identified with the highest parasites recorded was Capillaria spp. (64%: 16/25). Capillariasis caused hepatocytes to undergo necrosis and fibrosis with mononuclear infiltration surrounding Capillaria spp. eggs. Out of 16 samples positive for Capillaria spp., 12% (3/25) samples have co-infection with Cysticercus spp. which caused surrounding hepatocytes to compress. Samples with positive Sarcocystis spp. (60%: 15/25) showed pressure atrophy of myofibers and lymphocytic infiltrations. Strongyloides spp. (56%: 14/25) infection within the villi of small intestine showed eosinophilic and lymphocytic infiltration with villous atrophy. Moreover, Nippostrongylus spp. (32%: 8/25) and Hymenolepis spp. (8%: 2/25) were also found in intestinal mucosa. The lowest infection was Toxoplasma spp. (4%: 1/25) that was found in brain and kidney respectively and there was an infiltration of inflammatory cells seen. Overall, there were 100% (25/25) samples positive for zoonotic parasites illustrating a need to destroy any driven factors that accelerate rodents-pathogen transfer. This study provides an insight that the rats living in proximity with humans becoming vectors for diseases. Public awareness should be prioritised as this is a significant issue in public health as well.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	15 Nov 2024 01:53
Last Modified:	15 Nov 2024 01:53
URI:	http://psaspb.upm.edu.my/id/eprint/2118

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