Mohd Nor Shokri, Nur Afifah Afnie (2023) Histopathological findings of zoonotic parasites in rattus norvegicus captured in Klang Valley. [Project Paper] (Submitted)
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Abstract
Rattus norvegicus is a widespread species of common rats. It is commonly found in the wet market due to the abundance of food sources. This area also shows close proximity between the rats and human social activity in urban areas. They become carriers of many zoonotic diseases including rat lungworm disease, hepatic capillariasis, toxoplasmosis, sarcocystis and strongyloidosis that become major public health concerns. The objective of this study is to identify the parasites and examine the pathological lesions of zoonotic parasites in R. norvegicus around the Klang Valley areas. A total of 25 archived samples of R. norvegicus were processed for histopathological examination of selected organs of kidney, lung, liver, brain, spleen, heart, muscle, and intestine. The fixed samples were stained using Hematoxylin and Eosin staining methods and specimens were viewed under a light microscope at 4x, 10x and 40x magnifications. All 25 samples are positive for tissue parasites based on their histomorphology. Sarcocystis spp. was at the highest infection (83.3%:20/24) in muscle, followed by Capillaria hepatica (52%:13/25) and Cysticercus spp. (24%:6/25) observed in liver and Toxoplasma spp. in kidney (8%:1/25). Parasites observed in the intestine were suggestive of Strongyloides spp. (48%:12/25) and Hymenolepis spp. (4%:1/25). Histopathological lesions exhibited by the parasites can be seen in most samples including inflammatory infiltrates, eosinophilic inflammation, tissue necrosis, tissue fibrosis and the formation of parasites cyst and larvae. However, no parasites with insignificant changes were found in the brain, spleen, lung and heart. Overall, we found at least one zoonotic tissue parasite present in all samples that become a zoonotic threat among immunocompromised people such as infants, elderly and people with life-threatening disease. This study highlights the histopathological changes caused by zoonotic tissue parasites infection in rats of Klang Valley. Hence, it is important to control the population of rats in human living areas to avoid parasitic disease transmission to the human population.
| Item Type: | Project Paper |
|---|---|
| Faculty: | Faculty of Veterinary Medicine |
| Depositing User: | Ms. Nordeena Abdul Aziz |
| Date Deposited: | 15 Nov 2024 01:56 |
| Last Modified: | 15 Nov 2024 01:56 |
| URI: | http://psaspb.upm.edu.my/id/eprint/2120 |
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