Comparative histopathological analysis of solar-induced changes in canine cutaneous haemangioma and haemangiosarcoma

Chettiar, Aneetta Puvaneswaran (2023) Comparative histopathological analysis of solar-induced changes in canine cutaneous haemangioma and haemangiosarcoma. [Project Paper] (Submitted)

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Abstract

Cutaneous haemangioma (cHA) and haemangiosarcoma (cHSA) develop mainly in dog breeds with short-haired coats and lightly pigmented skin due to chronic exposure to solar radiation. The effect of solar exposure can be seen via solar-induced histopathological changes, namely sunburn cells, solar elastosis, actinic keratosis, and dermal fibrosis. The aim of this study was to compare solar-induced histopathological changes between canine cHA and cHSA, elucidating the effect of chronic solar exposure on tumour progression and its association with malignancy features in cHSA. Tissue blocks of canine cHA (n = 10) and cHSA (n = 20) diagnosed at the Histopathology Laboratory of the Faculty of Veterinary Medicine, UPM from 2018 to 2023 were evaluated for solar-induced histopathological changes, inflammation, tumour invasiveness and graded accordingly. The associations between solar-induced changes with malignancy features such as mitotic count, tumour differentiation and depth of invasion were assessed within cHSA group. Among the four solar-induced changes, dermal fibrosis was found to have significantly higher detection (P<0.05) in cHSA. Tumour invasiveness displayed significance between the tumour types, with a higher proportion of invasion into the hypodermis observed in cHSA. Inflammatory infiltrates were detected significantly higher in cHSA (P<0.05). There was no association found between solar-induced changes and malignancy features in this cohort of cHSA tumours. Cutaneous vascular neoplasms are a continuous spectrum ranging from benign to highly malignant. This study provides new insight into the histological characteristics of UV-associated cHSA in dogs. Notably, dermal fibrosis as one of the solar-induced changes, and other histopathology changes including inflammatory infiltrate, mitotic count, and depth of invasion of neoplastic cells into the hypodermis were useful features for differentiating cHSA from HA, and may help in detecting early malignant transformation of cutaneous vascular neoplasms.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms. Nordeena Abdul Aziz
Date Deposited:	18 Nov 2024 08:15
Last Modified:	18 Nov 2024 08:15
URI:	http://psaspb.upm.edu.my/id/eprint/2146

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