Fabrication of nano loaded jackfruit leaves emulsion by ultrasound method.

Nik Haron, Nik Syazwani (2018) Fabrication of nano loaded jackfruit leaves emulsion by ultrasound method. [Project Paper] (Submitted)

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Abstract

Jackfruit leaves have recently attracted attention for its therapeutic characteristics and cosmeceutical applications. It is believed that the artocarpin compound in the jackfruit leaves possess anti – inflammatory effect that capable in wound healing. Besides, it is reported that the jackfruit leaves also contain high amount of antioxidant properties which will be beneficial to the skin (Haswani Maisarah, 2018). However, delivering the beneficial attributes of the bioactive ingredients into formulation is challenging due to poor solubility and low bioavailability of bioactive substances. Nanoemulsion system is a emulsion containing two phases (oil & aqueous) and surfactant with droplet size in between 20-200 nm. This system have been used widely in the cosmetic and pharmaceutical area as crams, lotions, moisturizers and also foundation. Since human skin pore size are approximately in the range of 40-80 µm, the nanoemulsion system is the best approach to improve the efficiency of the bioactive extract in the jackfruit leaves. Therefore, nanoemulsion has been chosen to ensure and effective transdermal delivery of bioactive ingredients in jackfruit leaves extract for skin application. This study aimed to formulate an oil in water (O/W) nanoemulsions containing Jackfruit leaves extract in a cream form as well as to evaluate its physiochemical properties and the stability of nanoemulsions during eight (8) weeks of storage at room temperature at 45⁰C by high energy method which is ultrasound. In this work, Central Composite Design (CCD) was used to determine the optimal composition of the nanoemulsions. The optimum formulation of the nanoemulsions produces were at 80% water content, 0.93 O/S, and 25 minute ultrasonication time and 0.05% of extract of jackfruit leaves with the optimum particle size of 99.6 nm. The nanoemulsions possessed a pH compatible with skin pH (4.5 – 6.0); droplet size varying from 99.6 nm to 127.8 nm. Low viscosity of 1.72 mPa.s to 2.52 mPa.s and turbidity of 486 NTU to 521 NTU. Under the optimal conditions, the average droplet size obtained was 99.6 nm. The optimal nanoemulsions composition was observed to be stable under an accelerated stability study during storage at room temperature at 45⁰C for 60⁰C days. The optima formulation exhibit suitable physicochemical properties and stability against phase separation and coalescence which is desirable for skin products.

Item Type:	Project Paper
Faculty:	Faculty of Engineering
Depositing User:	Ms Siti Mariam Giman
Date Deposited:	13 Nov 2024 03:45
Last Modified:	13 Nov 2024 03:45
URI:	http://psaspb.upm.edu.my/id/eprint/2213

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