Antibacterial and cytotoxic activities from some selected plants

Foo, May Yin (2007) Antibacterial and cytotoxic activities from some selected plants. [Project Paper] (Unpublished)

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Abstract

Six plant extracts of four different species were studied for their antibacterial and cytotoxic activities. Methanol extract of leaf and stem from (Phy/lathus amarus, Senna alata, Cymbopogon nardus and Azadirachta excelsa) were screened for antibacterial activity against Vibrio parahaemolyticus, Escherichia coli, Listeria monocytogenes and Pseudomonas aeruginosa. The antibacterial activity was determined using disc diffusion method. Most of the extracts showed relatively potential antibacterial activity against all of the tested microorganisms with the diameter of inhibition zones ranging between 7.0 mm to 17.9 mm with the concentration of 1.9 mg/ml to I 000 mg/ml. All the plants studied, except the stem of Azadirachta excelsa, was active against the tested microorganisms and the stem of Senna alata was found to be selective against Vibrio parahaemolyticus. The most active plant extracts was Phyllathus amarus while the least active was Azadirachta excelsa (leaf) against all four strains of bacterial. The cytotoxic activities of six extracts were determined using Artemia salina and tested at three concentrations: I 0, I 00 and 1_000 µg/ml. All the extracts shown cytotoxic activity (LC50<1000 µg/ml) except for the leaf of Senna alata (LCso = 1 I 73.0). The methanolic extract leaf of Phyllathus amarus was the most active (LCso = 203.1) while with species moderate toxicity were the stem extracts of Senna alata (LCso = 415.5) and Azadirachta excelsa (LC50 = 573.4). Cymbopogon nardus (LCso = 680.8), the leaf extracts of Azadirachta excelsa (LC5o =1000.0) and Senna alata (LC50 =1173.0) were considered weak toxicity. The results obtained showed that the plants have potential antibacterial properties compare to cytotoxic properties. This can be selected for further investigation to determine its therapeutic potential as antibacterial agent.

Item Type:	Project Paper
Faculty:	Faculty of Agriculture and Food Sciences
Depositing User:	Mr. Azman Mohamad
Date Deposited:	17 Dec 2024 02:33
Last Modified:	17 Dec 2024 02:33
URI:	http://psaspb.upm.edu.my/id/eprint/2263

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