Antiulcerogenic effect of Momordica charantia on HCL/ethanol induced rats

Kamaldin, Mohd Nasier (2010) Antiulcerogenic effect of Momordica charantia on HCL/ethanol induced rats. [Project Paper] (Submitted)

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Abstract

Summary: Gastric ulcer is a common disorder where discontinuity in the gastric mucosa is observed. It is caused by many factors like stress, drugs, alcohol and is reported to be due to an imbalance between offensive acid-pepsin and defensive mucosal factors like mucin secreation and cell shedding. The conventional drugs used in the treatment of gastric ulcer include histamine (H2) receptor antagonists, proton pump inhibitors, antacids and anticholinergics. However, most of these drugs contribute various undersirable side effects and drug interactions. Use of natural drugs in gastric ulcers is well documented. Most of these drugs augment the mucosal defensive factors, which are thought to be important for protection of gastric mucosa. One such plant is Momordica charantia, used in traditional medicine against ulcer. It has been frequently used in folk medicine for rapid healing of cutaneous lesions and peptic ulcer in Asia and Africa. Therefore this study has designed to evaluate the effect of Momordica charantia seed oil on HC1/ethanol induced ulcer in experimental rats. Antiulcer assay performed by using HC1/ethanol combination methods. Animal pretreated for 7 days with distilled water (negative control), ranitidine (positive control-100 mg/kg) and with bitter gourd seed oil in various doses (100%, 50% and 10%) according to their body weight (10 m1/kg) and respective to the groups. On day 7, after one hour of pretreatment, animals fed orally with HC1/ethanol and one hour later, animals were sacrificed and proceed to macroscopic and microscopic assessment. From this study, M.charantia possess a significant anti-ulcer activity in HC1/ethanol – induced rats. The highest doses of treatment, XO-100%, showed the most effective and significant (p<0.005) result followed by XO-50% and XO-10. The XO-100% group show maximum inhibition of ulcer length and ulcer lesion by 90.95% and 68.96% respectively. XO-50% group inhibited ulcer length by 74.95% and ulcer lesion by 44.82%. The XO-10% is less effective in inhibition of ulcer length and ulcer lesion by 61.30% and 24.12% respectively. In future, this project could be able to explore a new concept of using bitter gourd seed oil as an anti ulcer agent instead of other remedy from traditional plant extract or existing therapy. This new agent not only reduces the problem associated with peptic ulcer but also provide therapeutic option for treating other type of ulcer.

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms Norafizah Radzuan
Date Deposited:	22 Nov 2022 07:36
Last Modified:	15 Feb 2023 01:31
URI:	http://psaspb.upm.edu.my/id/eprint/236

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