Use of colistin among patients in intensive care unit in Hospital Serdang and Hospital Sungai Buloh and its association with nephrotoxicity from 2010 until 2012

Wan Mahmud, Wan Mazuan and Ling, Siew Mei (2013) Use of colistin among patients in intensive care unit in Hospital Serdang and Hospital Sungai Buloh and its association with nephrotoxicity from 2010 until 2012. [Project Paper] (Submitted)

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Abstract

BACKGROUND: Colistin was originally used to treat Gram-negative infection particularly in critically ill patients (Reina, Estenssoro, Saenz, 2005) but early administration of this antibiotic was associated with reports of adverse effects in large number of patients (Brown, Dorman, Roy, 2005; Weser et aI., 2005). Due to re-emergence of Gram-negative bacteria to all antibiotics except colistin has led to reused of colistin (Falagas et aI., 2005). A lot of research has been done to make colistin as a life saving antibiotic over the world but however there is lack of local studies about the uses of colistin in Malaysia. OBJECTIVES: This study was designed to study the uses of colistin in intensive care unit in Hospital Serdang and Hospital Sungai Buloh and its association with nephrotoxicity. METHODS: One hundred (100) patients in intensive care unit who were administered with colistin between 2010 until 2012 in Hospital Serdang and Hospital Sungai Buloh were recruited and the collected data then were entered into SPSS. RESULTS: Colistin was mainly used in male (71 %) and malay (63%) patients. Most of the colistin was administered through intravenous route (82%). The daily dose and duration were within recommended range. Colistin was mainly used in treating pneumonia (47%) and sepsis (36%). There was increase trend of colistin use. Bacteria that was isolated most from patients with indication of colistin was Acinetobacter baumanni (71 %).70% of the sensitivity result showed colistin is sensitive against the bacteria isolated from patient. There was low rate of nephrotoxicity (23%). There is no significant association between daily dose (95% CI; p=.802) and duration of treatment (95% C; p=.562) and nephrotoxicity. CONCLUSION: In Malaysian Hospitals, most of the colistin is administered through intravenous route. The daily dose and duration is within the recommended range. There is low rate of nephrotoxicity after colistin administration. There is no significant association between daily dose and duration of treatment and nephrotoxicity. Keywords: Colistin, Nephrotoxicity

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Adni Syuhaida Zon
Date Deposited:	22 Nov 2022 08:18
Last Modified:	22 Aug 2023 01:29
URI:	http://psaspb.upm.edu.my/id/eprint/273

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