Retrospective survey on the common allergen specific IgE in pet dogs in Malaysia.

Lee, Wen Hai (2016) Retrospective survey on the common allergen specific IgE in pet dogs in Malaysia. [Project Paper] (Submitted)

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Abstract

Allergen is a substance, protein or non-protein, capable of inducing allergy or specific hypersensitivity which commonly term as allergy. It can be further classified into environmental or food source of allergens. In dogs, common environmental source of allergen such as house dust mite has been reported to be the common cause of canine atopic dermatitis in other countries. However, to date, there has not been any published studies on the common allergen specific IgE in pet dogs with atopy-like symptoms in Malaysia. The objective of this study is to determine the common allergen specific IgE among pet dogs with allergies symptoms in Malaysia. A retrospective study was conducted on records of 70 pet dogs suspected with allergy based on clinical symptoms, lesion types and localization that were tested for “Canine 62 Allergen Specific IgE Serological Test”, by EBS, Taiwan. Blood sample was submitted for serology testing by various small animal clinic practitioners in Malaysia from November 2012 to December 2015. Information such as breed, age of sample collection, sex, history (prior use of glucocorticoid, ectoparasitic treatment, lesion localization and types of lesions) were recorded. The serology data was classified into “Trace ( <500)”, “Mild (500-2000)”, “Moderate (2000-8000 )” and Severe (> 8000)”. Statistical analysis such as Mann-Whitney and Chi-square tests were carried out where appropriate to determine the significant difference and association of IgE measurements with clinical parameters (p<0.05). Tests were performed using SPSS version 23. Majority of the dogs included in this study were medium-small breed (64%), >3 years old (42%) and male (59%). There was a significant difference (p=0.006) between the environmental allergens as compared to food source. The three specific environmental allergens that caused the highest positive rates are mites (52.9%), fungi (38.6%) and pollen (32.9%). Among the five groups of mites, the Dermatophagoides farinae appeared to be the most important allergen (28.5% of dogs classified as “Moderate-Severe”). The Candida albicans (fungi) (30 %) and Cynodon dactylon (pollen) (25.7 %) appear to contribute as other important allergens among the dogs in this cohort. In conclusion, this study showed that environmental allergen especially house dust mite is the major cause of elevated specific IgE in pet dogs with allergy in Malaysia.

Item Type:	Project Paper
Faculty:	Faculty of Veterinary Medicine
Depositing User:	Ms Siti Mariam Giman
Date Deposited:	22 Nov 2022 02:37
Last Modified:	22 Nov 2022 02:37
URI:	http://psaspb.upm.edu.my/id/eprint/418

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