Assessing respiratory inflammation among children living near to Pajam landfill, Nilai using interleukin-6

Othman, Muhammad Syazwan (2014) Assessing respiratory inflammation among children living near to Pajam landfill, Nilai using interleukin-6. [Project Paper] (Submitted)

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Abstract

Introduction: Landfilling activities have potential to produce both fine and coarse particulates such as PM10. Exposure to the particulates that can enter the respiratory system is known to be associated with range of adverse effect on health. Children are more vulnerable to their environments than adults and for this reasons, they are among population that sensitive to the pollution. Instrument and Methodology: A cross-sectional comparative study design was used to determine the respiratory inflammation among children living near to the MSW landfill area. A total of 72 children were randomly selected based on the inclusive and exclusive criteria. A set of pre-tested questionnaire were utilized to obtain socio-demographic information and to predict health risk faced by the respondents. Saliva sample of the respondent were collected and were analysed using Humun Interleukin-6 (IL-6) Platinum ELISA (Enzyme-Linked Immunosorbent Assay) kit to determine the concentration level of the Interleukin-6 which indicates the respiratory inflammation faced by the respondents. Results: The PM10 concentration for the exposed group was higher than the unexposed group with the mean + standard deviation (SD) of 152.31 ± 3 1.07µg/m3 and 87.77 ± 30.77 µg/m3 respectively. The mean ± SD of the Interleukin-6 for the exposed group was slightly higher than the unexposed group with the mean ±SD of 6.34 ± 1.95 pglml and 5.77 ± 1.08 pg/ml respectively. The most common symptoms reported was sneezing and sore throat. There was no significant correlation between PMlo concentration and IL-6 in this study. Conclusion: The findings exhibit that there was no association between Interleukin-6 and PM PM10 concentration of the respondent. However, there are likely potential adverse health impacts arising from particulates exposure among exposed children in this study. Respondents are advised to have a medical check-up in order to determine respiratory health status thus elimination the risks of acquiring respiratory inflammation. Keywords: Respiratory inflammation, children, landfill, saliva. Interleukin-6

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Ms. Adni Syuhaida Zon
Date Deposited:	23 Nov 2022 03:29
Last Modified:	21 Mar 2023 03:44
URI:	http://psaspb.upm.edu.my/id/eprint/433

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