Association between air pollutants (UFP, PM₂.₅, PM₁₀, NO₂, and S0₂) with frequency of micronuclei (MN) in exfoliated buccal mucosa among primary school children nearby industrial area of Kemaman, Terengganu

Muhamad Daud, Siti Aishah (2016) Association between air pollutants (UFP, PM₂.₅, PM₁₀, NO₂, and S0₂) with frequency of micronuclei (MN) in exfoliated buccal mucosa among primary school children nearby industrial area of Kemaman, Terengganu. [Project Paper] (Submitted)

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Abstract

BACKGROUND Indoor air quality (IAQ) has become public health concern over the past year due to the health the acute or chronic exposure of indoor air pollutant will result in health problem most commonly associated with the respiratory system. Indoor air pollutants that possessed genotoxic effects are potential in inducing cell and genetic damage. Micronuclei (MN) frequency is used as an indicator for identifying potential genotoxic exposures. METHOD A comparative cross -sectional comparative study was carried out among Malay school children in industrial (N=111. Kemaman ) and suburban (N=65, Dungun) areas in Terengganu. Questionnaire adapted from ATS and American Academy of Paediatric was distributed to obtain respondents' background information, exposure history and reported respiratory symptoms. Exfoliated buccal mucosa sample was collected and analysed to determine the frequency of Micronuclei (MN). IAQ assessment was also carried out in a total of 6 schools and 60 respondents' houses in both study areas which include parameters of Ultrafine Particle (UFP), Particulate Matter (PM₂.₅, PM₁₀), Nitrogen dioxide (NO₂). Sulphur dioxide (SO₂), and Relative Humidity (RH). RESULT Results from statistical analysis show significant difference with p=0.001 for all parameter assessed between areas which includes UFP (z = -4.842), PM₂.₅,( z=-10.392), PM₁₀, z=-11.074, p=0.001; NO₂ (z=-11.868), SO₂ (z=-5.667), RH (z=-5.587). There was significant association between level of genotoxicity (based on higher and lower of MN frequency) and study areas (industrial and non-industrial area) with χ²=22.67, p=0.001. MN frequency was statistically significant with PM₂.₅ χ²=17.78, p=0.001) and PM (χ²=15.429, p =0.001). Statistical analysis shows significant association between UFP with cough (PR=2.965, 95% CI=1.069-8.225). Multiple logistic regression showed the main factor influenced MN frequency were UFP and NO₂ and MN frequency, UFP (p=0.005, PR=1.652, 95%CI= 1.167-2.338) and NO₂ (p=0.024, PR=1.008, 95% CI= 1.001-1.015) .CONCLUSION This study concludes that exposure to indoor air pollutants increase the risk of respiratory symptoms and might have impact on the MN frequency formed in exfoliated buccal mucosa. Keywords : Indoor Air Quality, Respiratory Health, Genotoxicity, Micronuclei (MN)

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Mr Muhamad Fazril Awang
Date Deposited:	23 Nov 2022 03:54
Last Modified:	23 Nov 2022 03:54
URI:	http://psaspb.upm.edu.my/id/eprint/498

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