Risk of Sarcopenia and its Associated Factors among Hemodialysis Patients in Selected Dialysis Centers

Low, Siao Jou (2021) Risk of Sarcopenia and its Associated Factors among Hemodialysis Patients in Selected Dialysis Centers. [Project Paper] (Submitted)

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Abstract

Sarcopenia is a well-known muscle disease of the elderly, and its prevalence in hemodialysis patients was revealed to be high. Despite its importance and growing clinical recognition, the issue of sarcopenia has not been fully addressed in the Chronic Kidney Disease (CKD) literature, with no relevant research in Malaysia. Therefore, this cross-sectional study aimed to determine the risk of sarcopenia and its associated factors in hemodialysis patients. In response to the difficulty of face-to-face interviews during the pandemic, physical copies of questionnaires were posted to the selected dialysis centers. Anthropometric and biochemical parameters were obtained as secondary data via dialysis records, with the supports of the dialysis center managers. Mini Nutrition Assessment (MNA), Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), Pittsburgh Sleep Quality Index (PSQI), and SARC-F questionnaire were used to assess nutritional status, depression, sleep quality, and risk of sarcopenia in the subjects, respectively. IBM SPSS version 25 was used in the statistical analysis, with a significance level was set at p < 0.05. A total of 102 subjects were recruited from three dialysis centers in Kinta District, Perak. The mean age of the subjects was 56 years. Hypertension was most prevalent (83.3%), followed by diabetes (43.1%), with nearly all of the subjects (94.1%) had polypharmacy. The prevalence of hypoalbuminemia and hyperphosphatemia was 56.9% and 52.9%, respectively. While a majority of the subjects experienced no weight loss in the past three months and had a mean BMI of 25.5 kg/m2, more than 60% of them were either at risk of malnutrition or were malnourished. Meanwhile, a total of 42.1% and 80.4% of the subjects had depression and poor sleep quality, respectively. There were 4 out of 10 subjects were at risk of sarcopenia, with Malays having the highest risk. In the bivariate analysis, risk of sarcopenia was significantly correlated with ethnicity (p=0.013), diabetes (p<0.001), serum albumin (r=-0.295, p=0.003), nutritional status (r=-0.450, p<0.001), depression (r=0.552, p<0.001) and sleep quality (r=0.198, p=0.046). In terms of sleep components, subjects with frequent sleep disturbances (r=0.210, p=0.034) and daytime dysfunctions (r=0.344, p<0.001) had significantly higher risk of sarcopenia. Despite methodological limitations, this study presented some important findings that may help policy makers and healthcare professionals in planning appropriate interventions to improve the sarcopenic status of hemodialysis patient

Item Type:	Project Paper
Faculty:	Faculty of Medicine and Health Science
Depositing User:	Mr Khoirul Asrimi Md Nor
Date Deposited:	21 Aug 2023 07:34
Last Modified:	21 Aug 2023 07:34
URI:	http://psaspb.upm.edu.my/id/eprint/922

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